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Structure and function of MMP-2 and its inhibitor TIMP-2
(2000-10-06)
Animal cells secrete various enzymes capable of degrading the extracellular matrix. One of the most studied groups of these are the matrix metalloproteinases (MMPs). This group of zinc containing endopeptidases consists ...
Interplay between mitochondria, primary cilium, diabetes and its complications
(2016-12-12)
Diabetes is one of the major health problems of the 21st century. Dysfunction of the insulin secreting pancreatic β-cell together with insulin resistance is central to the pathogenesis of type 2 diabetes mellitus (T2DM). ...
The impact of Bcl-2 family members on mast cell survival and apoptosis
(2008-10-31)
Mast cells are long-lived effector cells of the immune system perhaps best known for their involvement in allergic diseases. There are several acute and chronic inflammations where mast cell accumulation, activation and ...
Mortality and co-morbidity among patients with hemochromatosis and their first-degree relatives
(2010-05-14)
Genetic hemochromatosis (GH) is an autosomal recessive disease caused by
a C282Y mutation in the HFEgene, and is characterized by excess iron
accumulation in multiple organs. Classical manifestations of GH include
liver ...
Injuries, risk factors, consequences and injury perceptions in adolescent elite athletes
(2017-09-28)
Background: Injury and health data are not fully explored in adolescent elite athletes, yet essential for understanding injury risk, consequences of injuries and developing injury preventive programs.
Aims: To explore ...
Movement pattern, power generation and well-being in children and young adults with spastic unilateral cerebral palsy
(2011-03-07)
Patients with unilateral cerebral palsy (CP) all walk, most of them without great difficulty and without assistive devices. However, their walk tends to catch the eye because of abnormal, often asymmetrical movement in the ...
The red blood cell as a mediator of vascular dysfunction in type 2 diabetes and COVID-19
(2021-11-03)
Background: The number of patients diagnosed with Type 2 Diabetes (T2D) is steadily increasing and accounts for a large proportion of cardiovascular complications. Endothelial dysfunction represents an early disturbance ...
Geometric, biomechanical and molecular analyses of abdominal aortic aneurysm
(2020-08-20)
Background: Abdominal aortic aneurysm (AAA) is defined as a dilatation of the abdominal aorta of 30 mm in diameter or more. Main risk factors are smoking, age and male sex. Pathophysiological features include inflammation, ...
Interactions between neuroblastoma and the immune system : cellular pathways and mediators
(2011-03-04)
Neuroblastoma (NB) is an embryonal tumor of early childhood arising in tissues of the sympathetic nervous system, such as the adrenal gland and paraspinal ganglia. It is the most common extra-cranial solid tumor of childhood, ...
Notch signaling requiem : orchestral role of notch signaling in cancer and developmental disease
(2020-08-14)
Notch signaling is an evolutionary conserved contact-dependent cell-cell communication pathway. This “contact” spans from hydra to fruit flies to human; orchestrating development, homeostasis and cancer, thus the Requiem, ...