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Renal dysfunction and protection in cardiovascular surgery
(2000-09-15)
Purpose: This thesis is focused on studies of postoperative renal dysfunction (PRD), and on renal effects and possible prophylactic potentials of three vasoactive substances, calcitonin gene-related peptide (CGRP), atrial ...
Immunotherapy for pancreatic cancer
(2017-10-17)
Patients with pancreatic cancer have a short life expectancy, and only 20% of the patients diagnosed with pancreatic cancer can undergo surgery. Chemotherapy does not work well: Gemcitabine is the standard regimen with a ...
Estimation of gestational age by ultrasound and extreme prematurity
(2012-05-16)
from the EXPRESS study, which cover infants born prior to 27 weeks of gestation, revealed a one-year survival rate of 70%. The chance for survival without any major morbidity increased significantly with advancing gestational age at birth, from 9...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...
Improved statistical methodology for high-throughput omics data analysis
(2021-07-19)
Over the last two decades, the advent of high-throughput omics technology has substantially revolutionized biological and biomedical research. A large volume of omics data has been produced with the rapid development of ...
Understanding preclinical dementia : early detection of dementia through cognitive and biological markers
(2020-09-14)
Dementia is becoming a growing healthcare crisis, therefore identifying individuals at risk or in the earliest stages of dementia is essential if prevention or disease modification is to be achieved. The objective of this ...
Health promotion in diabetes care : studies on adult type 1 diabetes patients
(2008-05-02)
Introduction: A landmark report has shown that improving glycaemic
control among type 1 diabetes patients markedly reduces diabetes-related
complications. In clinical practice, however, many patients have problems
in ...
Metabolic monitoring in patients undergoing cardiac surgery using intravascular microdialysis
(2016-04-22)
Critically ill patients and patients undergoing cardiac surgery often experience hyperglycemia, hypoglycemia and glycemic variability (fluctuating blood glucose concentrations), all of which have been associated with adverse ...
The human ovary : a characterization of cell types and adverse ovarian side effects of chemotherapy
(2020-08-25)
The human ovary has a major role in the body’s endocrine and reproductive system. Understanding its cell type composition is crucial in order to study underlying mechanisms of hormonal balance and ovarian follicle maturation ...
Effects of DNA damage and vesicular exchange in P. falciparum
(2019-05-28)
Plasmodium falciparum causes human malaria and is a global leading cause of mortality from parasitic infections. While decades of concerted effort has yielded significant result in reducing the endemicity, there is evidence ...