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The role of CD30 in atopic allergy
(2000-10-26)
The 120 kDa CD30 molecule belongs to the tumour necrosis factor (TNF) receptor superfamily and is expressed by activated lymphoid cells. Small populations of CD30+ cells have been detected in the peripheral lymphoid organs, ...
Evolution and structure of leukotriene A4 hydrolase
(2001-10-12)
and the reproduction organs. Purification and characterization revealed a zinc metalloenzyme (69 kDa) with an anion-dependent peptidase activity. The toad LTA4 hydrolase converts LTA4 into LTB4 and delta6-trans-delta8-cis-LTB4, a metabolite which contracts the guinea...
The development of psychiatric disorders and adverse behaviors : from context to prediction
(2022-01-28)
Psychiatric disorders by definition cause significant impairment in an individual’s daily functioning. Certain disorders, such as borderline personality disorder (BPD) and eating disorders, have worse prognosis and high ...
The destiny of natural killer cells in the tumor microenvironment : to be suppressed or activated?
(2014-03-07)
In the mid-70s, the term “natural” was used based on the functional properties of NK cells where they recognize and lyse certain tumor cells without requirement of prior immunization. Although NK cells are “natural” in ...
Studies on the regulatory roles of cholesterol and bile acids
(2007-05-04)
into the primary bile acids cholic acid (CA) and
chenodeoxycholic acid, the ratio of which is determined by the enzyme
sterol 12 a -hydroxylase (CYP8B1). Both cholesterol and BAs regulate
their own synthesis, and other biological processes, through the actions...
Prospective cohort studies of disability pension and mortality in a Swedish county
(2007-09-04)
The overall aim of this thesis was to study risk factors for disability
pension, focusing on sociodemographic risk factors and sick-leave
diagnoses, and also to investigate the risk of mortality among disability
pension ...
Molecular and epidemiological studies of bladder exstrophy and epispadias complex
(2023-04-13)
Bladder exstrophy and epispadias complex is a rare congenital genitourinary malformation involving a midline closure defect, leaving an open bladder on the lower abdominal wall.
In Sweden, the prevalence is 3:100 ...
A 10-year follow-up of people with multiple sclerosis-aspects of disability and health, use of and satisfaction with care, and feasibility of cognitive behavioural therapy
(2014-11-21)
Background: Multiple sclerosis (MS) is a neuroinflammatory and neurodegenerative disease in the central nervous system which affects a number of life areas of the afflicted individual. Detailed knowledge is required on ...
Intelligence and cardiovascular health : epidemiological studies of swedish men
(2010-08-20)
Aim: A first aim of this thesis was to examine the relationship between intelligence in early adulthood and health outcomes, mainly cardiovascular morbidity and mortality, CVD, later in life using register-based data on ...
Cost analysis and policy implications in psychiatric care
(2009-04-01)
in Sweden in 2001 (Study I) was estimated at MSEK 85 774 (M€ 9 426, €1= SEK9.1). Indirect costs were totally predominant and constituted about 80% of the total cost, i.e. production losses due to early retirement, sickness absence and premature death...