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Visual dysfunction and ocular signs associated with periventricular leukomalacia in children born preterm
(1998-11-27)
The immature visual system is vulnerable to adverse events in infants born preterm. Both retinopathy of prematurity and periventricular leukomalacia may affect visual function and ocular appearance. The aims of the study ...
Postprandial lipaemia and its relation to premature atherosclerosis in middle-aged men
(2000-09-29)
The present research programme was set up to investigate whether pertubations of the metabolism of postprandial triglyceride-rich lipoproteins (TRLs) are related to premature atherosclerosis and to determine if treatment ...
Function, expression and polymorphism of human alcohol dehydrogenase 3/glutathionedependent formaldehyde dehydrogenase
(2001-05-02)
metabolism in human oral mucosa. A screen for allelic variants of ADH3 revealed four possible base pair exchanges in the promoter region: GG.197,-196 -4 AA, G-79 -4 A and C+9 g T. The AA-197,-196 allele was relatively common among Chinese, Spaniards...
The destiny of natural killer cells in the tumor microenvironment : to be suppressed or activated?
(2014-03-07)
In the mid-70s, the term “natural” was used based on the functional properties of NK cells where they recognize and lyse certain tumor cells without requirement of prior immunization. Although NK cells are “natural” in ...
A 10-year follow-up of people with multiple sclerosis-aspects of disability and health, use of and satisfaction with care, and feasibility of cognitive behavioural therapy
(2014-11-21)
Background: Multiple sclerosis (MS) is a neuroinflammatory and neurodegenerative disease in the central nervous system which affects a number of life areas of the afflicted individual. Detailed knowledge is required on ...
Time resolved functional brain networks : a novel method and developmental perspective
(2022-01-28)
Functional neuroimaging has helped elucidating the complexity of brain function in ever more detail during the last 30 years. In this time the concepts used to understand how the brain works has also developed from a focus ...
Natural killer cells in cancer : studies on migration and cytotoxicity
(2014-05-08)
The role of natural killer (NK) cells in cancer development has been studied extensively over the last four decades and the increasing knowledge on NK cell regulation has improved both safety and efficacy of treatment. ...
Mitochondria targeting and its consequences for cell death in neuroblastoma
(2018-12-14)
Mitochondria are one of the central regulators of several physiological and pathological processes. For instance, homeostatic glycolysis, citric acid cycle, and oxidative phosphorylation are all regulated by mitochondria. ...
Small artery dysfunction : focus on preeclampsia and end-stage renal disease
(2012-04-18)
Background: End-stage renal disease (ESRD) and preeclampsia (PE) are associated with high risk of cardiovascular events and characterized by endothelial dysfunction. Resistance arteries are actively involved in the control ...
Inflammatory arthritis and pregnancy
(2021-01-14)
The aim of this thesis was to add to the existing knowledge of how inflammatory arthritis disease affects pregnancy outcomes. In particular, the aim was to describe and study the effects of a diagnosis of juvenile idiopathic ...