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Neuronal and endocrine cells' susceptibility to physiologic and toxic stimuli : a study on the effects of steroid hormones
(2000-09-08)
The propensity of a cell to die can be influenced by a number of factors, including hormones, which affect the intracellular and extracellular milieu. The aim of this thesis was to investigate the effects of hormones on ...
Regulators of angiogenesis in diabetes and tumors
(2005-11-21)
and the potential risk of cellular oxidative damage. The master regulator of oxygen homeostasis is Hypoxia inducible factor-1 (HIF-1). Our basic hypothesis was therefore that HIF modulation might be relevant for diseases characterised by dysregulated angiogenesis...
Epidemiological studies on breast cancer risk factors and screening
(2023-09-27)
This thesis aims to enhance cancer prevention by investigating the factors and outcomes associated with false-positive (FP) mammography recalls, as well as understanding the association between breast cancer risk factors ...
Getting in and out of shape : relevance for organ formation and cancer
(2014-09-11)
A central question during development is how single cells form functional multi-cellular organ structures. The high reproducibility indicates intricate synchronization of cellular behaviors such as migration, proliferation ...
Mechanisms of chronic complications of diabetes with focus on mitochondria and oxygen sensing
(2009-12-25)
to hypoxia are mediated by the hypoxia-inducible factor-1 (HIF-1), which is an ubiquitary heterodimeric transcription factor, regulated by oxygen at the degradation level of its alpha subunit. The oxygen regulation of HIF is complex and involves a family...
Epidemiologic studies on acute appendicitis in children
(2018-04-12)
Acute appendicitis is the most common surgical emergency in children. A considerable effort has been made to develop and improve treatment and outcomes. A PubMed search yields over 20 000 publications on appendicitis. ...
Epidemiological studies of vacuum extraction delivery : incidence, risk factors and subsequent childbearing
(2014-11-10)
The aim of this thesis was to bring focus on factors and outcomes associated with vacuum
extraction delivery (VE). Delivery by VE is associated with both maternal risks (such as
obstetric anal sphincter ruptures, postpartum ...
Modelling and genetic correction of liver genetic diseases
(2021-03-24)
-humanized mice with hepatocytes from patients with UCD, OTC deficiency (OTCD) or carbamoyl phosphate synthetase 1 deficiency (CPS1D). Highly repopulated animals faithfully recapitulated the clinical manifestations of the disease observed in patients, including...
Brain function and behaviour related to development and training of working memory
(2005-10-28)
Training of working memory (WM) is a research field that could result in
new therapeutic breakthroughs for people with impaired WM functions. In
support of this view, research in our group has previously shown that ...
Pathogenic mechanisms behind dysregulated angiogenesis with focus on HIF and IGF-I signaling
(2013-09-12)
-I and HIF. We showed that IGF-I induced accumulation of both HIF-1α and HIF-2α paralogues. IGF increased also HIF activity as demonstrated by the HRE reporter gene assay and by induction of VEGF (classic target gene of HIF). We have further described...