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Studies on N-linked glycosylation in proliferation and viability of normal and tumor cells in vitro
(1996-05-10)
-prereplicative period (4-8 h after serum stimulation). High doses of insulin-like growth factor-1 (IGF-1) and insulin could overcome the inhibited DNA synthesis due to MVA-depletion, both in normal fibroblasts and in melanoma cells. The rescue of DNA synthesis...
Studies in safety promotion for preschool children
(2000-08-11)
The multifactorial aetiology in childhood injuries indicates a need for a systemic approach in the development of safety promotion strategies. In the present thesis, the feasibility of a systemic approach for the development ...
Toxicity of metal and metal oxide nanoparticles : the importance of physicochemical properties and cellular uptake
(2012-10-04)
The use of nanoparticles holds great promises in many technical as well as medical applications. However, development of new technologies, such as nanotechnology, is connected with uncertainties and risks. The same properties ...
Molecular epidemiology of tuberculosis
(2011-11-09)
Tuberculosis is a global epidemic, with one third of the world’s population estimated to be infected, around 9 million new active cases per year and close to 2 million deaths per year. Without adequate chemotherapy ...
Plasmodium falciparum response to chloroquine and artemisinin based combination therapy (ACT) in Guinea-Bissau
(2009-11-06)
Plasmodium falciparum causes the most severe form of malaria and is the most common malaria species in sub-Saharan Africa. Chloroquine used to be the most common drug for the treatment of malaria. Due to development of ...
Human ovarian follicles and oocytes : collection, cryopreservation, culture and gene expression
(2005-03-18)
Infertility affects approximately 15% of couples globally. The most effective treatment today is in vitro fertilization. However, not all couples can be helped with the current techniques. To achieve better success, ...
T cells in solid tumors : investigating the immunomodulation in the tumor microenvironment
(2018-09-03)
contradictory finding that a high FOXP3+ tumor infiltrating lymphocyte (TIL) number correlates positively to survival. In here, we answered that FOXP3+ CD4+ T cells in the tumor were real Tregs which protectively regulated tumor invasiveness by suppressing MMP2...
Treatment of uncomplicated malaria in Guinea-Bissau
(2006-03-10)
Treatment of malaria has become increasingly difficult due to high levels of resistance to the cheap and commonly used antimalarials. In Guinea-Bissau, the first line drug is chloroquine (CQ), the second line drug is ...
Disability pension due to common mental disorders : subsequent psychiatric morbidity and suicidal behaviour
(2017-01-30)
with subsequent suicidal behaviour (HR range: 1.15-3.89) (study I). Among the DP measures, stress-related mental disorders as main DP diagnosis, compared to depressive disorders were associated with a lower risk for subsequent suicidal behaviour (HR range: 0.4...
Physical activity, body mass index and prostate cancer : studies of risk, progression and mortality
(2015-03-06)
Prostate cancer is the most common cancer among men in developed countries, but it is still
unclear what causes the disease. Body mass index (BMI) and physical activity are modifiable
lifestyle factors with the potential ...