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Isolation and characterization of lipid-associated and neurosecretory polypeptides
(2000-05-19)
in extremely lipid-rich samples (90-98% lipids), where the protein content is low (1-5%), was developed. By derivatization of hydrolysed samples to their phenylisothiocarbamyl forms, and subsequent separation by reversed-phase HPLC, the amino acid content...
Clinical studies of glucose variability and hypoglycemia in adult patients with type 1 diabetes
(2011-11-02)
Diabetes mellitus type 1 is a condition characterized by elevated blood glucose values due to impaired insulin production. This condition is associated with increased morbidity from micro- and macrovascular complications. Studies have shown...
Biomarkers and outcome in children with hypoxic ischemic encephalopathy
(2021-11-04)
Approximately 1-6 per 1000 born infants will develop hypoxic-ischemic encephalopathy (HIE) with significant associated mortality and morbidity. For the past 45 years, severity of HIE has been stratified into mild, moderate, and severe. Seizures...
Vascular related pathologies in cardiovascular disease and cancer
(2017-04-28)
progenitor cells contribute to the injured vasculature and aid in the repair process. Yet the mechanisms underlying the amalgamation of the cells to the endothelium, their origin and functions have not been clear. Through Study 1 using animal models...
New potential targets in medulloblastoma therapy : studies on cellular mechanisms and mediators
(2010-01-15)
Medulloblastoma is an embryonal tumour that mainly affects children. It
is the most common malignant brain tumour in children and accounts for
15% of all childhood brain tumours. It most often presents in the
cerebellum ...
The relation among aging, dopamine-regulating genes, and neurocognition
(2020-10-07)
on grey-matter (GM) volume in striatum in older adults, and examined whether the genetic effect interacts with age. Results showed that the A allele of the DRD2/ANKK1-Taq1A polymorphism was associated with smaller GM volume in caudate and this effect...
Assessment and differential diagnosis in childhood apraxia of speech
(2022-05-24)
errors. More CAS characteristics were evident in the DA sample (on average 6.8), than in SA sample (5.2). In Study IV the number of parent-reported functional difficulties ranged from 1 to 27 across the participants. The hierarchical cluster analysis...
Modelling and calculation of DNA damage and repair in mammalian cells induced by ionizing radiation of different quality
(2013-05-21)
Recent experimental data have revealed a wealth of information that provides an exceptional opportunity to construct a mechanistic model of DNA repair. The cellular response to radiation exposure starts with repair of DNA ...
Exosomes : the future of vaccination?
(2011-11-25)
activation was absent in Bruton kinase knockout (btk-/-) mice lacking a functional B cell compartment. Further, we found that bone marrow DC-derived exosomes express CD1d and can activate natural killer T cells (NKT cells) in vitro and in vivo. Activation...
Long-term outcome after hypothermia-treated hypoxic-ischaemic encephalopathy
(2022-05-13)
Hypoxic-ischaemic encephalopathy (HIE) is a major cause of acquired brain injury in newborn infants. It is a potentially life-threatening condition that leaves survivors at substantial risk of life-long debilitating sequelae ...