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Visualising the invisible : exploring interactive video in HIV prevention in rural Zambia
(2000-05-04)
The purpose of this thesis is to explore and develop video as an interactive method that can be used in HIV prevention, in order to facilitate reflexivity, communication and dialogue about HIV/AIDS among people. In this ...
Microenvironmental regulation of neural stem cell differentiation
(2014-11-21)
The central nervous system consists of complex networks of neurons and other specialized cells that process information from within and outside the organism to create an output. The development of this complex machinery ...
Immunopathogenesis of multiple sclerosis : big roles for small RNAs
(2020-05-21)
hypermethylation at the VMP1/MIR21 locus in CD4 T cells of MS patients compared to controls. Moreover we found lower expression of miR-21 and consequently an upregulation of its targets genes. Our functional investigation using murine MS-like disease further...
Generation and investigation of neural microenvironment in health and disease
(2019-10-09)
neural stem cells (NSCs). By applying different metabolic conditions in vitro, we showed that hypoxia and 2-Deoxy-D-glucose increased acetylation of CtBP2 in proliferating NSCs. Additionally, 1% oxygen treatment resulted in altered homodimerization of Ct...
Customization of tamoxifen therapy : not only a dream
(2011-09-06)
to apply information from cell lines to find patient-based associations with potential clinical utility. The response to tamoxifen may be dependent on the involvement of VEGF and RARA. The predictive value of CAPS and MX1 remains to be elucidated...
Modelling and calculation of DNA damage and repair in mammalian cells induced by ionizing radiation of different quality
(2013-05-21)
Recent experimental data have revealed a wealth of information that provides an exceptional opportunity to construct a mechanistic model of DNA repair. The cellular response to radiation exposure starts with repair of DNA ...
Skin cancer in relation to tobacco use and organ transplantation
(2009-01-02)
smoking was, however, unrelated to risk of CSCC. Snuff use was associated with a 40% decreased risk of CSCC, compared to non-tobacco users. A BMI ≥25 kg/m2 was associated with a 1.3-fold increased risk of CMM, compared to a BMI<25 kg/m2...
Stable high-sensitivity cardiac troponin T levels and outcomes
(2018-11-15)
Background: Many patients who seek medical attention because of chest pain in the emergency department (ED), without myocardial infarction (MI) as a final diagnosis, will have cardiac troponin (cTn) levels above the upper ...
Mechanistic insights into the biosynthesis of polyketide antibiotics
(2006-11-24)
biosynthetic enzymes. The crystal structures of two polyketide cyclases, SnoaL and AknH were determined to 1.35Å and 1.9Å respectively. These enzymes share very similar α+β structural folds and catalyze a novel type of intramolecular aldol condensation reaction...
EBV membrane protein LMP2A interactions with ubiquitin ligases and a signaling scaffold
(2004-09-24)
perturbation of cellular systems are relevant model systems for learning about the normal functions of the cell and for pointing to vulnerable functions that are targeted also in non-viral disease, as in cancer. In the present thesis I provide evidence that: 1...