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Molecular studies in breast cancer susceptibility genes
(2000-05-09)
Breast cancer is the most common malignancy among women, with a cumulative risk of approximately 12% by the age of 85. Of the breast cancer cases, 5-10% are hereditary. To date, several breast cancer susceptibility genes ...
The cell cycle regulators p15, p16, p18 and p19 : functions and regulation during normal cell cycle and in multistep carcinogenesis
(2000-09-29)
The tumor suppressor protein p16INK4a and its family members p15INK4b, p18INK4c and p19INK4d (the INK4 proteins) inhibit the cyclin-dependent kinases CDK4 and CDK6, which are key regulators of the retinoblastoma protein ...
Mapping the Golgi retention signal in the G1 membrane glycoprotein of Uukuniemi virus, a member of the Bunyaviridae family
(1999-01-15)
. The glycoproteins are inserted in the membrane as type I membrane proteins with their C-terminal tails exposed in the cytoplasm. Using the T7 RNA polymerase-driven vaccinia virus expression system we found that G1 expressed alone was targeted to and retained...
Single cell analysis of iPS derived neural stem cells and neurons
(2019-11-21)
In vitro derived neural stem cells can be used to model events of neurogenesis and neurodevelopmental dysfunction. Formation of stable neural stem cell environments relies on cellular components to stabilize cell-to-cell ...
Cat allergy : diagnosis and characterization of important allergens
(2008-05-09)
Allergy affects about 25% of the population. Allergic diseases are
manifested in many ways, from mild rhinitis to life-threatening
anaphylaxis. Globally, more than 15% of children and adults are allergic
to pets.
The ...
Exploring the impact of diabetes in Sudan : out-of-pocket expenditure and social consequences of diabetes on patients and their families
(2017-08-10)
Diabetes mellitus in Sudan is a growing health problem in all socio-economic classes. The natural history of the disease is associated with poor of glycaemic control, a high prevalence of complications and a low quality ...
Risk factors for rheumatoid arthritis : epidemiological studies of perinatal characteristics, infections and the inflammatory reflex
(2009-11-13)
Rheumatoid arthritis (RA) is a chronic inflammatory disease that is characterised by symmetric polyarthritis leading to progressive joint destruction. The aim of this thesis was to contribute to better knowledge of the ...
Early indicators for adverse development of cardiovascular, renal and metabolic function in children born with low birth weight
(2018-08-17)
to follow up consequences of prematurity or low birth weight at term compared to term controls with normal birth weight in two different cohorts. The first cohort of children, studied at a mean age of 9.7 and again at 12.6 years (studies I-III), were born...
Structural and functional studies of Malassezia sympodialis-derived allergens
(2008-03-21)
Atopic eczema (AE) is a chronic inflammatory skin disease characterised
by pruritic (itchy) skin lesions. The pathogenic mechanisms underlying AE
are still unclear, although several factors such as genetic
predisposition, ...
Depression and cardiovascular diseases
(2018-09-28)
Background and aim: The concept of depression as a risk factor for cardiovascular diseases (CVD) is now well known. However, weather the severity of depression has a dose response effect on risk of CVD is not known. Also ...