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Well-being among the very old : a survey on a sample aged 90 years and above
(2000-04-07)
This thesis examines well-being among the very old and the factors believed to influence the three components of well-being called life satisfaction, positive affect and negative affect. It also examines activity patterns, ...
The development of psychiatric disorders and adverse behaviors : from context to prediction
(2022-01-28)
of machine learning algorithms to assess predictive performance. The sample included 7,638 twins from the Child and Adolescent Twin Study in Sweden (CATSS). Our model was able to predict the outcome with reasonable performance but is not suitable for use...
Translational genomics of HIV-1 subtype C in India : molecular phylogeny and drug resistance
(2013-05-16)
This thesis describes the translational genomics of HIV-1subtype C in India from its origin to therapeutic response with the aim to improve our knowledge for better therapeutic and preventive strategies to combat HIV/AIDS. ...
Depression in youth and adults : etiology, outcomes, and comorbidities
(2022-02-02)
Depression is a common and debilitating mental disorder characterized by low mood, loss of interest in activities, and long-lasting functional impairment. It is a worldwide psychiatric illness with a wide range of ages of ...
Probing and pushing potential genetics, development and training of cognitive functions
(2012-05-15)
Capacities of cognitive functions increase considerably during childhood and adolescence. This development is of importance as poor development can predict lower performance on academic skills. Furthermore, severe impairment ...
Inflammation and cytokine production in experimental neuroinflammatory disorders
(2013-09-04)
Glutamate excitotoxicity is involved in the pathogenesis of a variety of neurodegenerative disorders, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and multiple sclerosis (MS). Kainic acid (KA), an analogue ...
Dynamic mechanical allodynia in peripheral neuropathic pain : psychological observations
(2009-02-27)
Introduction and aim: Pain due to a light moving mechanical stimulus,
dynamic mechanical allodynia, is a protruding symptom/sign in subgroups
of patients with peripheral neuropathic pain and frequently as
troublesome ...
Neural correlates of individual differences in personality and intelligence : studies using an isochronous timing task and voxel based morphometry
(2009-01-14)
It is easy to imagine that humans have always noticed the differences
between themselves and others and perhaps even speculated about the
origins of these differences. The study of individual differences as a
formal ...
Biomarkers and outcome in children with hypoxic ischemic encephalopathy
(2021-11-04)
Approximately 1-6 per 1000 born infants will develop hypoxic-ischemic encephalopathy (HIE) with significant associated mortality and morbidity. For the past 45 years, severity of HIE has been stratified into mild, moderate, ...
Pharmacological and analytical studies of the cyclin dependent kinase inhibitors
(2009-10-30)
, glomerulonephritis and inflammatory diseases. (R)-roscovitine (Rosco) is a synthetic tri-substituted purine that inhibits selectively Cdk1, 2, 5, 7 and 9. Rosco has shown promising cytotoxicity in cell lines and tumor xenografts. Rosco so far has only demonstrated...