Search
Now showing items 1-9 of 9
Biological determinants of HIV infection : studies of viral evolution during disease progression in children and adults
(2000-02-04)
Coreceptor usage of primary HIV-1 isolates was analysed in relation to their biological phenotype and the severity of HIV-1 infection in the patient. The indicator cell lines, U87 glioma cells engineered to express CD4 and ...
Linking quantitative radiology to molecular mechanism for improved vascular disease therapy selection and follow-up
(2022-09-08)
4411 proteins, demonstrating a range of 39-96% plaque instability. Simulations of drug responses varied in patients with initially unstable lesions from high (20%, on combination therapy) to marginal improvement, whereas patients with initially stable...
Effects of proteasome inhibitors on chondrogenesis and linear bone growth
(2013-05-07)
Linear bone growth occurs at the growth plate, a thin layer of cartilage between the epiphysis and metaphysis of long bones. In the growth plate, resting/stem-like chondrocytes divide and generate the highly proliferative ...
Prevention of growth failure caused by glucocorticoid treatment
(2023-03-10)
. Mechanistic studies in ex vivo cultured human growth plate cartilage showed suppressed endogenous humanin expression in tissues exposed to IBD serum or the pro-inflammatory cytokine TNF. Interestingly, we also observed that the expression of PCNA, SOX-9...
Effects of chemotherapy on bone growth and chondrocyte cell death signaling
(2010-11-01)
of dexamethasone-induced growth retardation. By investigating these mechanisms, we found that dexamethasone activates caspase-8, -9 and -3 in proliferative chondrocytes. In addition, the Akt-PI3K signaling pathway, which plays a key role in the survival...
Molecular basis for trimethoprim and sulphonamide resistance in Gram negative pathogens
(2006-08-11)
Resistance to antibiotics is becoming an important global public health problem. Infectious diseases are still among the major causes of disease and death in many parts of the world and the possibilities to treat bacterial ...
Carbon-graphite fiber-reinforced polymers for implant suprastructures
(2009-04-03)
Carbon-graphite fiber-reinforced polymers (CGFR) can be used as the core material for implant-retained prostheses as an alternative to metal frameworks. The purpose was to formulate and develop carbon-graphite fiber-reinforced ...
Regulation of cellular degradation pathways by viral oncoproteins and microRNAs
(2020-10-08)
The cellular degradation system actively participates in cell homeostasis. Despite ongoing efforts and much progress in recent years, the underlying mechanisms of these pathways are not entirely understood. This thesis ...
Genetic determinants of breast cancer risk
(2011-01-19)
The main purpose of this thesis was to identify genetic risk factors using both hypothesis-based and hypothesis-free approaches.
In an attempt to identify common disease susceptibility alleles for breast cancer, we ...