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Neurobiological basis of the nicotine withdrawal reaction : an experimental analysis
(2000-01-28)
The mesolimbocortical dopamine (DA) system is pivotal for the mediation of the reinforcing effects of many dependence-producing drugs. It consists of cell bodies in the ventral tegmental area (VTA) that project to e.g. the ...
Epstein-Barr virus and genomic instability : a new look at the mechanisms of viral oncogenesis
(2010-12-20)
revealed a significant increase in dicentric chromosomes, chromosome fragments and chromatid gaps in EBV infected cells. EBV latency I, where only EBNA1 is expressed, was sufficient for this effect, whereas a stronger increase was observed in latency III...
Structural enzymology of oxalate degradation in Oxalobacter formigenes
(2008-01-04)
Oxalic acid, as one of nature's most highly oxidised compounds, is toxic
to most organisms. It is introduced in the human body in the diet but
also as a waste product of cellular metabolism. Mammals do not posses ...
Integrated assessment of environmental and human health risks of antibiotic residues and resistance for environmental and health policy
(2021-04-27)
Background: Antibiotic resistance is a global health crisis and a serious threat to progress in achieving the Sustainable Development Goals. This requires a One Health response that recognises the link between human and ...
Molecular mechanisms in synaptic vesicle recycling
(2010-09-03)
Neurons communicate through specialized contacts called synapses, which consist of pre- and postsynaptic compartments separated by a narrow synaptic cleft. The stimulus- dependent rapid influx of calcium ions into the ...
Conditions for care : factors in the nurse work environment related to safe and high quality care in acute care hospitals
(2018-12-20)
Shortages of registered nurses (RNs) intensify challenges for healthcare service providers in matching an increasing demand for care with a sufficient healthcare workforce. Poor working conditions have been recognized to ...
Effects of DNA damage and vesicular exchange in P. falciparum
(2019-05-28)
Plasmodium falciparum causes human malaria and is a global leading cause of mortality from parasitic infections. While decades of concerted effort has yielded significant result in reducing the endemicity, there is evidence ...
Cost analysis and policy implications in psychiatric care
(2009-04-01)
in Sweden in 2001 (Study I) was estimated at MSEK 85 774 (M€ 9 426, €1= SEK9.1). Indirect costs were totally predominant and constituted about 80% of the total cost, i.e. production losses due to early retirement, sickness absence and premature death...
Tracking selective attention in a musical cocktail
(2021-08-18)
The cocktail party effect refers to mankind’s ability to focus attention on a single sound within noisy or complex auditory environments, in order to extract the most behaviourally-relevant information present. To investigate ...
Advancing cancer immunotherapy by exploring NK cell education, antibody targeting and tissue homing : stay tuned for directions reaching beyond the natural biology
(2022-10-21)
of NK cell subsets, we uncovered that LIR-1 could educate ex vivo expanded NK cells while resting LIR-1-expressing NK cells were hyporesponsive against missing-self tumor cells. In contrast to other educated NK cell subsets, LIR-1-expressing ex vivo...