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Transcriptional regulation of the neuropeptide galanin : special reference to axotomy
(1999-11-19)
Galanin is a neuropeptide which is located in both the central and peripheral nervous system. In peripheral neurones, this peptide is thought to be involved in influencing pain sensation after nerve injury (neuropathic ...
Dissecting the roles of viral T-antigens in Merkel cell carcinoma
(2022-04-11)
of miRNAs. These miRNAs suppressed autophagy by targeting the key autophagy genes ATG7, SQSTM1 and BECN1. Concordantly, low expressions of ATG7 and SQSTM1 were lower in virus-positive tumors. In addition, treatment with Torin-1 (mTOR inhibitor) induced...
Inhibition of apoptosis by the Us3 protein kinase of herpes simplex virus 1
(2004-09-10)
The Herpes Simplex Virus 1 (HSV-1) US3 protein kinase is part of the anti-apoptotic arsenal that salvage HSV-1-infected cells from damage caused by different stimuli. The Us3 gene encodes a protein kinase that phosphorylates ...
Basis for reclassification of nasopharyngeal carcinoma
(2012-03-22)
.6%) were histologically classified as undifferentiated epithelial cell carcinoma (UECC), 942 (24.5%) as undifferentiated mixed epithelial-sarcomatoid cell carcinoma (UESCC), 640 (16.7%) as undifferentiated sarcomatoid cell carcinoma (USCC), and 200 (5...
Immune response during hepatitis B virus infection and reconstitution of HBV-specific immunity using T cells redirected against HBV
(2013-08-27)
-specific T cells produced CXCL-8, but not IL-17, during periods of liver inflammation in acute or chronic patients. HBV-specific T cells producing CXCL-8 could be expanded from acute/resolved patients in the presence of IL-7 and IL-15, suggesting that virus...
Regulation of cellular degradation pathways by viral oncoproteins and microRNAs
(2020-10-08)
with the mRNA level of the FBXW7 ubiquitin E3 ligase. Overexpression of miR-223-3p suppressed, while its inhibition increased, FBXW7 protein level in TGCT cell lines, suggesting FBXW7 as a target of miR-223-3p. Using both gain- and loss...
Antibiotic use and resistance : patterns, perceptions, policy and the price to pay
(2014-05-08)
Background: Antibiotic resistance is a major health challenge especially in low and middle income countries such as India. Inappropriate antibiotic use is one important factor contributing to resistance. Strategies to ...
Molecular characterization of phenothiazines in experimental cancer therapy : new tricks of an old drug revealed
(2012-04-04)
Cancer is characterized by uncontrolled malignant proliferation of cells that eventually interfere with tissue/organ functions. Traditionally, cancer is treated with chemo- and/or radiotherapy when surgery is not an option. ...
Roles of NUDT5 and NUDT15 beyond oxidized nucleotide sanitation and their potential as therapeutic targets
(2018-03-15)
The nucleotide precursor pool is readily susceptible to numerous sources of modification and damage, including alkylation, deamination and oxidation/nitrosylation, among others; most of which have deleterious effects on ...