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Quantitative cataract measurement with the Scheimpflug technique
(1999-11-12)
Cataract is the most prevalent blinding eye disease. Scheimpflug photography is an objective method for documentation of lens nuclear opacity. Using the Scheimpflug slit-lamp technique, a photograph, in focus from the ...
Cortical plasticity in response to median nerve trauma
(2016-11-11)
Median nerve injuries in adults, repaired with nerve suture, lead to incomplete functional recovery despite improved surgical technique. This results in a reduction in quality of life, poorer working ability and a considerable ...
Endometriosis and ovarian reserve : inflammation and prognostic markers
(2008-04-18)
Introduction: Endometriosis is a common, benign gynecological disease,
associated with pelvic pain and infertility. It is generally thought to
be caused by retrograde shedding of menstrual tissue with subsequent
attachment ...
Cost analysis and policy implications in psychiatric care
(2009-04-01)
in Sweden in 2001 (Study I) was estimated at MSEK 85 774 (M€ 9 426, €1= SEK9.1). Indirect costs were totally predominant and constituted about 80% of the total cost, i.e. production losses due to early retirement, sickness absence and premature death...
Severe asphyxia due to substandard care during labour
(2010-03-19)
Aim: The objective of the thesis was to describe the most common causes of
substandard care during labour contributing to severe asphyxia or
neonatal death, to study risk factors related to asphyxia associated with
substandard ...
Clinical studies on drug treatment of hospitalised patients : general infectious diseases and acute myocardial infarction
(2013-05-03)
. We found that CYP2D6 is a major factor of metoprolol disposition and effects in AMI patients and also a major determinant of individual variability of response to the treatment. Common exogenous medications prescribed for treatment of depression...
Studies on HIV-1 core assembly
(2007-11-02)
The main objective of this thesis was to define the roles of Gag (p55), in particular, the capsid (CA, p24) protein in human immunodeficiency virus type 1 (HIV-1) particle assembly. More specifically, i) to determine the ...
Tumor acidosis in malignant progression and therapy
(2016-04-06)
H. Finally, we developed a model of drug screening performed on cancer cells chronically adapted to pH 6.8 in order to identify compounds targeting cells in metabolic stress conditions. We identified Verteporfin as a promising new anticancer drug able...
Neutrophil-induced endothelial barrier dysfunction in acute inflammation : mechanisms and therapeutic strategies
(2020-01-17)
The acute inflammatory response is characterized by recruitment of leukocytes and increased vascular permeability, resulting in the cardinal signs of inflammation; redness, heat, swelling, pain and loss of function. ...
Roles of NUDT5 and NUDT15 beyond oxidized nucleotide sanitation and their potential as therapeutic targets
(2018-03-15)
in cancer cells neither affected cell survival nor oxidized nucleotide content of DNA. The NUDT15 crystal structure explained this deviation from MTH1 and shows that 8-oxo-dGTP is poorly accommodated in the enzyme active site. We also identified 6-thio...