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Changes in sensory systems during aging : an experimental study in the rat
(1999-11-26)
of neuron loss and the extent of behavioral deficits. Analysis of B4 and RT97, used as markers for small unmyelinated and large myelinated primary afferent neurons, respectively, clearly indicate that DRG neuron loss is unselective with regard to neuron...
Function, expression and polymorphism of human alcohol dehydrogenase 3/glutathionedependent formaldehyde dehydrogenase
(2001-05-02)
metabolism in human oral mucosa. A screen for allelic variants of ADH3 revealed four possible base pair exchanges in the promoter region: GG.197,-196 -4 AA, G-79 -4 A and C+9 g T. The AA-197,-196 allele was relatively common among Chinese, Spaniards...
Consequences of multiple sclerosis for patients in Sweden
(2019-11-11)
This study aimed to consider consequences of multiple sclerosis for patients in Sweden throughout various stages of the life course. The thesis was separated into four constituent papers, which dealt with different aspects ...
Application of next generation sequencing in genetic and genomic studies
(2016-07-07)
Genetic variants that spread along the human genome play vital roles in determining our
traits, affecting development and potentially causing disorders. Most common disorders have
complex underlying mechanisms involving ...
Role of PfATP6 and pfMRP1 in Plasmodium falciparum resistance to antimalarial drugs
(2009-05-11)
Half of the world's population live at risk for malaria and nearly one million people die from the disease every year. The malaria burden is greatest in children and pregnant women in sub-Saharan Africa. As effective ...
Mechanistic insights into the biosynthesis of polyketide antibiotics
(2006-11-24)
Anthracyclines are a group of aromatic polyketide compounds with significant medical importance due to their antineoplastic properties. Doxorubicin and daunorubicin members of this family are among the two most commonly ...
Epidermal stem cells at the point of no return
(2023-05-17)
The skin is our main barrier against outside harm, and it helps to maintain internal
homeostasis. These functions are mostly fulfilled by the epidermis, which is the
outermost layer of the skin, formed from keratinocytes ...
Plasmodium falciparum drug transporter genes in emerging malaria multidrug resistance
(2011-03-24)
Malaria is caused by an intracellular protozoan parasite of the genus Plasmodium. The use of chemotherapy, the foremost tool available for the control of the disease, has been challenged in the last decades by the development ...
Lost in transition? A study of newly graduated teachers' experiences during the initial period of employment
(2011-04-06)
questionnaires. Two data collections were performed during the final two years of education and three during the initial three years of employment. A total of 4,067 student teachers from the whole of the country with approximately two years left...