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Genetic vaccination against acute viral disease
(1999-11-12)
This thesis describes the development of recombinant vaccines based on the Semliki Forest virus (SFV) expression system. Immunisation of mice with recombinant virus particles, a layered DNA/RNA plasmid vector, and recombinant ...
Prenatal nicotine exposure and effects on the health of the newborn
(2017-03-30)
Maternal smoking is one of the most important preventable risk factors in pregnancy. Whether it is nicotine or combustion products, or possibly both, that cause the adverse effects is not clear. The common substance in ...
Regulation of eukaryotic cell physiology using organic bioelectronics
(2011-03-25)
. The specific physiological concepts that the devices aimed to address were activation of voltage-gated ion channels, cellular mechanotransduction and cell adhesion. The conductive polymers that were used in these devices were polypyrrole and poly(3...
The role of X-ray imaging and musculoskeletal ultrasound in the diagnosis and management of rheumatoid arthritis
(2014-10-31)
with early RA who responded well to initial Methotrexate (MTX) monotherapy. Most early RA patients who achieved low disease activity after 3 – 4 months of MTX monotherapy continued to have low disease activity during 2 years follow-up. However, marked...
Genetic studies in familial non-BRCA breast cancer
(2017-11-09)
an overrepresentation of endometrial cancer in the non-BRCA families with a 6.36 % proportion (CI 4.67–8.2) compared to the proportion in the general population in the reference years 1970 (3.07 %) and 2010 (2.64 %). The main finding of the study was the strong support...
Epidemiological studies on breast cancer risk factors and screening
(2023-09-27)
This thesis aims to enhance cancer prevention by investigating the factors and outcomes associated with false-positive (FP) mammography recalls, as well as understanding the association between breast cancer risk factors ...
Mechanisms of chronic complications of diabetes with focus on mitochondria and oxygen sensing
(2009-12-25)
Chronic complications of diabetes represent a major medical and economical concern. It is an imperative need to establish the pathogenic mechanisms that contribute to development of chronic complications in order to design ...
New diagnostic approaches for venous thromboembolism and thrombophilia
(2020-05-15)
Background: Venous thromboembolism is a serious disease comprising both pulmonary embolism and deep vein thrombosis. Venous thromboembolism causes considerable mortality and morbidity, with residual symptoms such as pulmonary ...
Structural studies of lumazine synthases : thermostability, catalytic mechanism and molecular assembly
(2005-12-27)
Riboflavin, also known as vitamin B2, is biosynthesized in plants, bacteria, archaea and fungi. The primary biological function of riboflavin is related to its existence as a component of the two coenzymes, flavin ...
Studies of stem cell and adhesion proteins in breast cancer
(2014-10-06)
Breast cancer is the commonest cancer and second leading cause of cancer death in women. It has been shown that breast cancer tumorigenic/stem cell like cells are CD24-/low CD44+EpCAM+. These cells constitute less than 5% ...