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Genetic analysis of human astrocytic gliomas : xenografts as a research tool
(1999-11-26)
Cancer is a genetic disorder of somatic cells. An accumulation of genetic changes is believed to result in neoplastic transformation and malignant progression. In humans, astrocytic gliomas are the most common primary ...
Genetic studies of frontotemporal dementia : with particular emphasis on the tau gene
(2001-05-11)
Frontotemporal dementia (FTD) is next to Alzheimer's disease one of the
common causes of early onset progressive dementia. FTD is mainly
characterized by personality changes such as disinhibition, although
there are ...
Associations of breast cancer risk prediction tools with tumor characteristics and metastasis
(2020-04-23)
Purpose: The association between established risk factors for breast cancer and subtypes or prognosis of the disease is not well known. We analyzed whether the Tyrer-Cuzick–predicted 10-year breast cancer risk score (TCRS), ...
Type 1 diabetes in pregnancy : perinatal outcome with special reference to fetal macrosomia
(2012-04-16)
The aim of this epidemiological study was to elucidate whether in recent years, obstetric and perinatal outcomes in pregnancies complicated by type 1 diabetes (T1DM) have improved or not. The objective was also to identify ...
Molecular and epigenetic control of CNS tumour and progenitor cells
(2017-02-09)
Despite advances in diagnosis and treatment, CNS tumours continue to result in high mortality and morbidity. Glioblastoma mutliforme (GBM), the most common primary brain tumour, is a recurrent tumour that despite advances ...
Genetics in dementia : impact of sequence variations for families and populations
(2010-03-26)
Even though the human genome sequences are remarkably similar, there is
room for genetic variability that makes every human unique. The most
common form of sequence variation in the genome is an exchange of a
single ...
Measures to prevent microembolization in cardiac surgery and during angiography with special reference to carbon dioxide
(2020-02-21)
Background: Cardiovascular interventions including open heart surgery using cardiopulmonary bypass (CPB) and coronary angiography may introduce air and particulate arterial embolism that may lead to tissue lesions of the ...
To cut or not to cut? Episiotomy in vacuum extraction
(2022-04-05)
. The third-degree perineal injuries alone were reduced from 14.0% to 10.9% (-3.1, 95% CI -3.7 to -2.4) with NNT 32. The fourth-degree perineal injuries alone were reduced from 1.6% to 1.0 % (-0.6%, 95% CI -0.8 to -0.4). Fourth-degree perineal injuries...
A multi-omics approach to uncover estrogen receptor (ER) and activator protein 1 (AP-1) signaling networks in breast cancer
(2019-09-27)
breast cancer cell model with overexpression of ERβ in the absence of ERα. We used CRISPR/Cas9 system to knock out ERα in MCF7 breast cancer cells with stable Tet-Off-inducible ERβ expression. We found that only ERβ-expressing MCF7 cells displayed a...
Mechanisms of chronic complications of diabetes with focus on mitochondria and oxygen sensing
(2009-12-25)
Chronic complications of diabetes represent a major medical and economical concern. It is an imperative need to establish the pathogenic mechanisms that contribute to development of chronic complications in order to design ...