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Genetic dissection of experimental autoimmune neuroinflammatory diseases in rats
(1999-10-18)
Multiple Sclerosis (MS) is a chronic inflammatory and demyelinating disease of the central nervous system (CNS) causing neurological deficits. The disease has a complex etiology comprising multiple unidentified susceptibility ...
Microenvironmental regulation of neural stem cell differentiation
(2014-11-21)
The central nervous system consists of complex networks of neurons and other specialized cells that process information from within and outside the organism to create an output. The development of this complex machinery ...
Coagulation during and after cardiopulmonary bypass with focus on heparin, protamine, aprotinin and platelet function
(2019-05-10)
, respectively, undergoing cardiac surgery with CPB were randomized to heparin and protamine dosage based on body weight only or the HeProCalc algorithm. In Study III ROTEM® and ROTEM®platelet were analysed before anaesthesia (T0, n=23), after CPB (T1, n=23...
Structure-function studies of plasminogen activator inhibitor-1
(1998-11-20)
Plasminogen activator inhibitor-I (PAI-1) is an important physiological inhibitor of tissue-type plasminogen activator (tPA) and urine-type plasminogen activator (uPA). High plasma levels of PAI-1 correlate to thrombotic ...
Personality traits among individuals who as adolescents consulted for a substance use problem
(2013-03-15)
Background: Adolescent antisocial behavior including substance misuse is associated with negative consequences both for the individual and the society, for example school drop-out, and high costs in the criminal justice ...
Pituitary regulation of plasma lipoprotein metabolism and intestinal cholesterol absorption
(2005-11-18)
Increased levels of plasma cholesterol are associated with a higher risk to develop atherosclerosis, the leading cause of death in Western societies. The major part of cholesterol in human blood is transported within ...
Enhanced recovery after surgery (ERAS) interventions and outcome from colorectal surgery
(2021-01-04)
with shorter LOS (mean 5.6 vs 9.0 days, p < 0.001), lower risk of complications (odds ratio (OR) 0.44, 95 % confidence interval (CI) (0.28 – 0.71)) and symptoms delaying discharge (OR 0.47, 95 % CI (0.32 - 0.70)). The risk of cancer specific death...
Effects of chemotherapy on bone growth and chondrocyte cell death signaling
(2010-11-01)
Glucocorticoids (GCs) are widely used in both children and adults to treat common inflammatory diseases, including asthma, rheumatoid arthritis, ulcerative colitis and Crohn’s disease. However, a multitude of undesired ...
Colorectal cancer : aspects of multidisciplinary treatment, metastatic disease and sexual function
(2012-02-17)
More than 6000 people in Sweden are diagnosed with colorectal cancer annually. One out of five patients already has metastases at diagnosis. However, the occurrences of metastases at specific locations, e.g. peritoneal ...
Chemokine receptor expression and function in experimental autoimmune neuroinflammation
(2007-05-25)
Neuroinflammatory lesions in the central nervous system (CNS) are characterized by the presence of leukocytes, mainly monocytes/macrophages, derived from the systemic compartment. We believe CC inflammatory chemokine ...