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Regulation of prostaglandin E2 synthesis in human gingival fibroblasts
(1999-10-08)
Prostaglandins, especially, prostaglandin E2 (PGE2) play an important role in inflammatory diseases such as rheumatoid arthritis and periodontitis.
The aim of the present thesis was to study the production and the ...
Physical activity and health-related quality of life in older adults with osteoporosis
(2015-08-26)
activity. The odds ratio (95% CI) for having a daily step-count ≥5,000 was 6.17 (1.23-30.91), p=0.027, for the intervention group compared to controls. The effect was not associated with improvements in gait speed, balance, or falls self-efficacy and did...
Quality of life and sexual health among transgender people and people living with HIV in Sweden
(2019-01-18)
Background: The overarching objective of public health policy in Sweden has a clear focus on equitable health throughout the population and includes a commitment to reduce avoidable health inequalities. Trans (transgender) ...
Developmental origins of polycystic ovary syndrome : role of early adverse life events on adult health
(2020-03-17)
The research focus of this thesis is polycystic ovary syndrome (PCOS), the most common endocrine disorder among women of reproductive age, associated with reproductive, cardio-metabolic, and mental health complications. ...
Studies of stem cell and adhesion proteins in breast cancer
(2014-10-06)
Breast cancer is the commonest cancer and second leading cause of cancer death in women. It has been shown that breast cancer tumorigenic/stem cell like cells are CD24-/low CD44+EpCAM+. These cells constitute less than 5% ...
Immunological alterations, therapies with immune check-point inhibitors and beyond in patients with metastatic melanoma
(2020-10-07)
In the last decade the treatment of metastatic melanoma (MM) has been revolutionized and changed the life of many patients, offering prolonged survival and improved symptom control. These treatment strategies have also ...
Hemophagocytic lymphohistiocytosis and associations with malignancies
(2023-05-10)
and the Swedish national cancer register. We report an almost three-fold increased incidence rate of all cancers in mothers of patients with HLH compared to matched controls (4.4 vs 1.6, p=0.0014). In paper II we investigated individuals diagnosed with lymphoma...
Global regulation of gene expression in stem cells and regeneration
(2017-08-17)
Rapid developments in genomics and transcriptomics fields have made it possible to ask new questions as well as solve various old problems in biology that were not achievable previously. Novel techniques such as RNA ...
Sex differences in cancer risk and survival
(2019-11-15)
Aim: The objective of study I was to delineate and quantify sex differences in cancer risk and survival together with assessing the potential gain achieved by eliminating the excess cancer risk in men. Study II and III ...
Strategies to optimize natural killer cell functions in the tumor microenvironment
(2023-10-13)
Immune cell-based therapies are currently changing the oncological treatment landscape worldwide. While genetically modified T cells have already been approved for clinical use in few hematological cancers, natural killer ...