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Dopaminergic and serotonergic modulation of cellular and locomotor network properties in the lamprey spinal cord
(1999-09-03)
. DA and 5-HT both reduce the late afterhyperpolarization (AHP) following the action potential and thereby depresses spike frequency adaptation. While 5-HT via the activation of 5-HT1A-like receptors reduces the late AHP through a direct action...
Atrial fibrillation and lifestyle factors with focus on physical activity and alcohol consumption
(2017-02-06)
The overall aim of this thesis was to investigate how modifiable lifestyle factors, with a focus on alcohol consumption and physical activity, influence the risk of atrial fibrillation (AF). The thesis is based on data ...
Anatomical and functional characterization of serotonergic neurocircuitry
(2016-12-19)
The serotonin system arises from a small collection of brainstem structures called the raphe nuclei and innervates much of the central nervous system. A relatively small number of serotonin neurons modulate a wide variety ...
Gene expression profiling in periodontitis
(2015-02-06)
The chronic inflammatory disease periodontitis is characterized by destruction of periodontal tissue, i.e. the tissues that surround and support the teeth. This complex disease is multifactorial, involving oral pathogens, ...
Depression and cardiovascular diseases
(2018-09-28)
of mental health, work and relations among adults > 20 years of age residing in Stockholm County, Sweden. The study included three data collections, wave 1 (W1) in 1998–2000, wave 2 (W2) in 2001–2003 and wave 3 (W3) in 2010. In total 10,443 individuals were...
Impaired response to HBV vaccination in HIV-1 infected children : immunopathological mechanisms
(2018-05-08)
HBV vaccination prevents HBV infection and related liver cancer. Immunological dysfunctions of Tfh and B cells in HIV-1 infected individuals may affect the response to HBV vaccine. The general objective of this thesis was to elucidate HBV vaccine...
Immunological alterations, therapies with immune check-point inhibitors and beyond in patients with metastatic melanoma
(2020-10-07)
in the immune system, in addition to those related to T-cells, during treatment with anti-CTLA 4 and anti-PD1 antibodies. In addition, we conducted a phase I trial with adoptive T cell therapy (ACT) with or without dendritic cell (DC) vaccination...
Vascular related pathologies in cardiovascular disease and cancer
(2017-04-28)
progenitor cells contribute to the injured vasculature and aid in the repair process. Yet the mechanisms underlying the amalgamation of the cells to the endothelium, their origin and functions have not been clear. Through Study 1 using animal models...
Adipose markers of metabolic outcome after weight loss
(2019-02-28)
Adipose tissue is closely linked to metabolic disturbances in obesity. Bariatric surgery such as roux-en-Y gastric bypass (RYGB) remains the most effective treatment of obesity and obesity-related disease. More factors ...
Epidemiological studies of suicide : classification bias, drug use, and social circumstances
(2013-04-12)
Despite the decline in suicide rates in Sweden during the past decades, suicide still constitutes a severe public health problem and is a cause of death that to a large extent could be prevented. In 2008 the Swedish ...