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Leukotriene C4 synthesis and export in human platelets and leukocytes : LTC4 synthase expression in normal and leukemic myeloid cells
(1999-09-03)
Leukotriene (LT)C4 synthase catalyses conjugation of the unstable epoxide LTA4 with reduced glutathione and is the rate-limiting enzyme in the formation of cysteinyl leukotrienes, powerful mediators of asthma and ...
Respiratory activity in medulla oblongata and its modulation by adenosine and opioids
(1998-10-30)
with increasing foetal and postnatal age. Chronic matemal intake of caffeine (an adenosine antagonist) during gestation increased the pontine inhibition of medullary respiratory activity in perinatal pups (E18-P3). In addition, the anoxia-induced gasping...
Understanding cellular and cytoskeletal dysregulation in immunodeficiency diseases
(2019-12-18)
The immune system is a complex network of cells and molecules interacting to preserve the integrity and survival of the host by distinguishing self from non-self, and dysregulation of immune cells can lead to immunodeficiency, ...
Statistical methods for the detection, analyses and integration of biomarkers in the human genome and transcriptome
(2014-09-09)
Most human diseases have been shown to have a genetic basis that is linked to regulation of gene expression at the transcriptional or post-transcriptional level. In the central dogma of biology, deoxyribonucleic acid (DNA) ...
Rescue of mutant p53 family members by the low molecular weight compound PRIMA-1MET/ APR-246
(2010-11-12)
The tumor suppressor p53, guardian of the genome, is induced and activated by cellular stress signals such as DNA damage, hypoxia and activation of oncogenes. p53 upregulates downstream target genes, that are involved in ...
Exploring the transcriptome of the brain
(2014-05-14)
Our knowledge of the transcriptome has become much more complex since the days of the central dogma of molecular biology. We now know that splicing takes place to create potentially thousands of isoforms from a single gene, ...
Risk indicators for esophageal cancer : some medical conditions and tobacco-related indicators
(2007-05-14)
Because of little progress in the prognosis and survival of esophageal
cancer patients, the early diagnosis and prevention have been
prioritized. Alcohol consumption and tobacco smoking are the main risk
factors of ...
Functional assays for the diagnosis of primary defects in lymphocyte cytotoxicity
(2015-11-02)
TCR engagement. The CD8+CD57+ T cell subset, similar to CD56dim NK cells, was found to display defective degranulation in FHL types 3-5, suggesting CTL and NK cell exocytosis has similar molecular requirements. In paper VII, we compared the established...
Investigation of the genetic basis of familial non-BRCA1/2 breast cancer
(2005-12-30)
haplotype analysis revealed an association between one common haplotype G-A-G and increased risk of sporadic breast cancer (OR=3.0 p=0.03). This result suggests a role for ESR2 in breast cancer. (Paper IV)...
Optimization of pediatrics antiretroviral treatment outcomes among HIV infected children in Ethiopia
(2019-12-11)
enrolment, 177(25.1%) and 83(11.8%) had high aspartate aminotransferase and alanine aminotransferase (ALT), respectively. Zidovudine or nevirapine containing regimens and viral load >1000 copies/mL were associated with elevated ALT. Twenty-four (3.4%) and 84...