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Factors influencing the evolution of HIV-1
(1999-10-25)
Due to the high replication rate and the low fidelity of the viral reverse transcriptase (RT), various mutations are introduced continuously into the gene pool of HIV-1. Together with recombination events this leads to the ...
Regulation of eukaryotic cell physiology using organic bioelectronics
(2011-03-25)
The field of organic bioelectronics deals with the implementation of conducting polymer science in biology and medicine. The purpose of this thesis was to develop organic bioelectronic devices for the regulation of eukaryotic ...
Genetic studies in familial non-BRCA breast cancer
(2017-11-09)
an overrepresentation of endometrial cancer in the non-BRCA families with a 6.36 % proportion (CI 4.67–8.2) compared to the proportion in the general population in the reference years 1970 (3.07 %) and 2010 (2.64 %). The main finding of the study was the strong support...
A novel drug and device in anesthesia : with focus on breathing and upper airway physiology
(2018-04-12)
Anesthesia-related airway complications are associated with hypoxia due to inability to secure or maintain the airway with subsequent insufficient ventilation and gas exchange. This thesis has explored the impact on airway ...
Nitric oxide in exhaled gas : studies on physiological regulation and measurements in infants and children
(1999-09-16)
Nitric oxide (NO) is found in the exhaled gas of humans, starting from birth, and is increased in adult patients with bronchial asthma. This study assessed whether the measurement of NO in exhaled gas is technically feasible ...
Apoptosis and inflammation regulation after injury to the developing brain
(2015-09-25)
The brain shows greater plasticity in early life than in maturity, which paradoxically renders the organ more vulnerable to hypoxia-ischemia (HI)- and cranial irradiation (IR)- induced damage. Apoptosis after a HI insult ...
The emergence and preservation of sick building syndrome : research challenges of a modern age disease
(1999-05-21)
Since the 1970ies, the sick building syndrome (SBS) has become a common health problem. It is usually defined as a state of ill health consisting of subjective symptoms from mucous membranes and skin, as well as of' general ...
Diagnosis and treatment of Helicobacter pylori infection in Vietnamese children
(2009-11-20)
with eradication rates (OR 8.13, 95% CI 2.23-29.6). These differences were not seen for the LAM regimen. Low age was the most prominent independent risk factor for reinfection (adjusted HR among children aged 3-4, 5-6, and 7-8 years, relative to those aged 9...
Immunomodulation and its effector mechanisms in atherosclerosis
(2007-05-11)
Atherosclerosis is a disease of the arterial intima, characterized by
cholesterol deposition, inflammation and fibrosis. The pathogenesis of
atherosclerosis is related to both innate and adaptive immune responses,
and ...
Review and prediction of trauma mortality
(2018-09-28)
Quality management principles stipulate that outcome after injury is dependent upon patient factors, injury severity, structures and processes of care in a trauma system. Structures refers to the context in which care is ...