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Surfactant treatment in neonatal group B streptococcal pneumonia : experimental and clinical studies
(1999-10-06)
Surfactant dysfunction is probably involved in the pathophysiology of neonatal group B streptococcal (GBS) pneumonia. Aim of the present studies was to evaluate efficacy and safety of surfactant replacement therapy for ...
Synaptic uncoupling in the mouse cochlea induced by noise or cisplatin and its clinical relevance
(2020-03-12)
The cochlea has an autonomous circadian clock that controls auditory function and increases vulnerability to noise trauma during the active phase. The mechanisms regulating the circadian control of the auditory system are ...
Molecular regulation and analysis of neural stem and cancer cell characteristics
(2012-05-25)
Every single cell within an organism is constantly facing the demanding task of preserving the integrity of its genomic material to secure proper function and clearance from disease. To accomplish this cells rely on DNA ...
The DNA repair enzymes MTH1 and OGG1 as targets to treat inflammation
(2021-11-25)
Chronic and acute inflammatory diseases, such as multiple sclerosis (MS), psoriasis and sepsis, account for vast disability and morbidity in the world. Several new immunomodulating treatment alternatives have been developed ...
Conserved structure-function relationships in the mediator complex
(2007-02-16)
The Mediator complex is an essential multiprotein coregulator of RNA polymerase II (pol II)- dependent transcription in fungi and metazoans. Mediator interacts directly with both pol II and sequence-specific transcriptional ...
Roles of Myc and Mad in cell cycle and apoptosis
(2006-05-12)
induced by etoposide, doxorubicin, and cisplatin. Furthermore, we found that etoposide and doxorubicin signaling involved activation of pro-apoptotic Bax and of caspase 3 and 9. In addition, etoposide required proapoptotic PKCdelta for efficient apoptosis...
Optimization of HIV and tuberculosis co-treatment in Tanzania : drug-drug interactions and clinical outcomes
(2013-02-06)
lower body mass index, Karnofsky scores and haemoglobin compared to those with HIV only, despite similar baseline CD4 cell counts. Mortality was similar in both the HIV only and those with HIV-TB, being 10.9% (16 deaths/100person years) and 11.3% (17...
Unraveling the role of NOTCH3 dysfunction in disease and for therapy development : a focus on CADASIL
(2021-08-20)
The Notch signaling pathway, including the Notch3 receptor, is involved in many pivotal contexts of cell signaling and cell fate determination processes during development and in adulthood. Different mutations in the NOTCH3 ...
Sex hormones in gastric mucosal physiology and the development of oesophageal, gastric and colorectal adenocarcinoma
(2022-05-19)
The aim of this thesis was to continue to test the hypothesis that sex hormones play some part in the aetiology and seem to protect women from the development of oesophageal, gastric, and colorectal adenocarcinoma. All ...