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CD8+ T cell specificity in thymic selection and in the recognition of antigen
(1999-08-27)
-specific event where peptide dependency varies between T cells.
Mice lacking a functional ß2-microglobulin (ß2m) gene express very low levels of properly conformed MHC class I molecules, and cae therefore serve as a model system for CD8+ T cell selection where...
Molecular studies of multiple endocrine neoplasia type 1 (MEN1)
(2000-08-25)
SCG1 and SCG2. We demonstrated that SCG2 was ubiquitously expressed as a 2.9 kb transcript. Mutation analysis of this gene using SSCP on MEN1 individuals demonstrated the presence of inactivating frameshift, missense or nonsense mutations, which...
Fat mass, adipokines and clinical complications of chronic kidney disease
(2006-05-26)
Patients with chronic kidney disease (CKD), irrespective of initial etiology, have a risk of cardiovascular morbidity (CVD) and mortality that is many-fold higher than that of a similar person without CKD. While traditional ...
Negative experiences of encounters in healthcare
(2013-05-22)
. Statistical analysis of Attributable Risk (AR) with 95% CI. Results: Response rate 58%. 1 628 of the respondents had experiences of negative encounters in healthcare, and of these 1 036 reported also having felt wronged. Types of negative encounters...
Survival and renal function after acute kidney injury : epidemiological and biomarker studies
(2018-01-10)
) than in the non-AKI group. Study II examined the impact of pre-existing renal dysfunction on survival and development of ESRD. Five-year mortality was highest in patients with Acute on Chronic disease (AoC) being 71.3%, for the CKD group it was 68.2...
Shoulder and upper extremity impairments, activity limitation and physiotherapeutic exercise in women with rheumatoid arthritis : a biopsychosocial approach
(2000-05-04)
predominantly personal hygiene activities. Still, the shoulder and upper-extremity variables indicated activity limitation and overall SIP to a rather small extent (11.330.2 %). Static and dynamic shoulder rotator endurance training in a group of women (n=37...
Interleukin-22 binding protein in multiple sclerosis and experimental inflammation models
(2017-10-20)
of the established genetic risk factors, the single nucleotide polymorphism (SNP) rs17066096. Since this SNP is positioned close to the gene IL22RA2, we hypothesize that IL22RA2 mediates the effect on MS susceptibility. The gene product of IL22RA2 is interleukin-22...
Cutaneous leishmaniasis : treatment and genetic mechanisms affecting outcome
(2022-08-25)
Leishmaniasis is a neglected parasitic disease and a rare diagnosis in non-endemic countries in Europe. Migration, geopolitical conflicts and climate change have increased awareness of this infection in Europe, as more ...
Effects of proteasome inhibitors on chondrogenesis and linear bone growth
(2013-05-07)
Linear bone growth occurs at the growth plate, a thin layer of cartilage between the epiphysis and metaphysis of long bones. In the growth plate, resting/stem-like chondrocytes divide and generate the highly proliferative ...
Integrated assessment of environmental and human health risks of antibiotic residues and resistance for environmental and health policy
(2021-04-27)
Background: Antibiotic resistance is a global health crisis and a serious threat to progress in achieving the Sustainable Development Goals. This requires a One Health response that recognises the link between human and ...