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SLE : pathogenetic mechanisms in nephritis and sulphasalazine-induced lupus reactions
(1999-11-01)
Systemic lupus erythematosus (SLE) is an autoimmune disease with a multifactorial and largely unknown etiology, in which genetic and environmental factors are known to influence disease susceptibility and expression. ...
A clinical epidemiological study on end-stage liver disease in Ghana
(2022-06-01)
of 44 years, with most patients presenting at an advanced stage of disease. APRI cut-off of 2 had sensitivity of 45.4% and specificity of 95% in the diagnosis of cirrhosis, whilst a cut-off of 1 had sensitivity of 75.9% and specificity of 89%. The AUC...
Small molecules as research tools for studying the biology of the tumour suppressor p53
(2011-05-24)
p53 is a potent tumour suppressor that is inactivated in the majority, if not all human
cancers. In about 50% of the cases, the gene is mutated and in the rest it is rendered
inactive mainly by deregulation of its ...
Intelligence and cardiovascular health : epidemiological studies of swedish men
(2010-08-20)
Aim: A first aim of this thesis was to examine the relationship between intelligence in early adulthood and health outcomes, mainly cardiovascular morbidity and mortality, CVD, later in life using register-based data on ...
Determinants of hearing impairment in Swedish hunters : an e-epidemiological approach
(2016-04-08)
Background: 290 236 persons bought a hunting license in Sweden 2014/15. Hunters are
spread all over the country and come from all socioeconomic groups. Recreational fiearms
can produce peak noise levels between 156-164 ...
Early indicators for adverse development of cardiovascular, renal and metabolic function in children born with low birth weight
(2018-08-17)
Prematurity affects more than 10% of infants worldwide and is the main reason for neonatal mortality. Improvements in neonatal care have led to higher survival rates into adulthood. Adverse events during organogenesis and ...
Translational genomics of HIV-1 subtype C in India : molecular phylogeny and drug resistance
(2013-05-16)
-cell counts. In addition, older children with HIV-1 subtype C infection presented a high prevalence of predicted X4 and R5/X4 tropic strains which indicates that HIV-1 subtype C strains required longer duration of infection and greater disease progression...
In vitro studies on anti-leukemic effects of tetracycline's analogues and cyclophosphamide
(2015-05-25)
Leukemia is a heterogeneous group of hematological malignancies that originate from the bone marrow. Leukemias are classified as acute or chronic. Although acute leukemia affects patients of all ages, acute lymphoid leukemia ...
Antibody-associated inflammation in and outside the joint in rheumatoid arthritis
(2017-08-17)
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by pain, chronic inflammation and joint destruction. Epidemiological investigations in large populationbased cohorts have identified both genetic ...
Molecular and epidemiological investigations of lung involvement in very early rheumatoid arthritis
(2015-11-26)
Rheumatoid arthritis (RA) is a systemic inflammatory joint disease with at least two distinct clinical phenotypes defined by the presence or absence of antibodies, i.e. rheumatoid factor (RF) and/or anti-citrullinated ...