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Hypercoagulation in preeclampsia : implications for maternal health and fetal growth
(1999-05-21)
function cause intrauterine growth retardation (IUGR). Increased incidence of coronary heart disease in later life has been shown in women with a history of PE.
Objectives: 1) To assess in PE, whether hypercoagulation depends on deficient function...
Consequences of CYP2D6 polymorphism for the disposition and dynamics of tolterodine : a novel drug in the treatment of urinary bladder overactivity
(1998-11-20)
was determined. The effect of tolterodine on the major drug metabolizing cytochrome P450 (CYP) isozymes 1A2, 2C19, 2D6 and 3A4 was studied in vivo by measurements of metabolic ratios of probe drugs. Changes in tolterodine disposition during potent CYP2D6...
T-lymphocyte mediated killing of TAP-deficient tumor cells and immunodominance of minor histocompatibility antigens
(1998-05-04)
(B6) mice, if transfected with the gene for the costimulatory molecule B7-1 (CD80). Efficient killing required the presence of MHC class I molecules, and the absence of TAP-function, in the target cells. CTL elicited by RMA-S.B7- 1 killed TAP...
Structure-function studies of plasminogen activator inhibitor-1
(1998-11-20)
Plasminogen activator inhibitor-I (PAI-1) is an important physiological inhibitor of tissue-type plasminogen activator (tPA) and urine-type plasminogen activator (uPA). High plasma levels of PAI-1 correlate to thrombotic disease, and low levels can...
Register-based studies of infertility and the use of assisted reproductive techniques : possibilities and challenges
(2022-08-04)
The implementation of assisted reproductive techniques (ART) has enabled over 10 million births in the past 45 years. Concern for excess risks of adverse birth outcomes has largely, but not entirely, been mitigated by ...
Determinants of hearing impairment in Swedish hunters : an e-epidemiological approach
(2016-04-08)
Background: 290 236 persons bought a hunting license in Sweden 2014/15. Hunters are
spread all over the country and come from all socioeconomic groups. Recreational fiearms
can produce peak noise levels between 156-164 ...
Molecular regulation and analysis of neural stem and cancer cell characteristics
(2012-05-25)
and VPA treatment respectively. In addition, we show that RNA knockdown of the DNA glycosylase OGG1 in C6SCs affects differentiation potential and increases the histone modification mark, acetylation of histone 3 in lysine 56 (H3K56ac) associated...
Epidemiological studies on breast cancer risk factors and screening
(2023-09-27)
This thesis aims to enhance cancer prevention by investigating the factors and outcomes associated with false-positive (FP) mammography recalls, as well as understanding the association between breast cancer risk factors ...
Nursing interventions in radiation therapy : studies on women with breast cancer
(2000-02-11)
The general aim of this thesis was to acquire knowledge to be used to improve the care of cancer patients during and after radiation therapy, in particular for women with breast cancer. The specific objectives were first ...
Bilateral cochlear implants in children : clinical and methodological studies
(2015-11-16)
A cochlear implant (CI) restores functional hearing in individuals with bilateral severe-
to-profound sensorineural hearing loss. Despite hearing loss in both ears, CIs
are usually provided unilaterally, excluding the ...