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Inducible and constitutive modes of gene regulation by the dioxin receptor and Arnt
(1999-05-14)
Heterodimeric complexes between the basic helix-loop-helix (bHLH)/PAS (Per-Arnt-Sim) transcription factors, dioxin receptor and Arnt, are involved in mediating cellular responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin ...
Effect of hyperglycemia on glucose transport and intracellular signal transduction in skeletal muscle
(1999-05-19)
Recent studies revealing the components of insulin signal transduction have raised the question of whether the defects in insulin signaling account for disturbed glucose metabolism in people with NIDDM. The major focus of ...
Early cardiovascular risk markers and cardiac function in children with chronic kidney disease
(2016-04-08)
Children with advanced chronic kidney disease (CKD) have an increased risk of premature death, foremost due to cardiovascular disease (CVD). The cardiovascular (CV) morbidity starts early in the disease process and renal ...
Roles of Notch signalling in early embryonic development
(2011-11-24)
Metazoan embryonic development requires a complex interplay of morphological processes coordinated with self-renewal and differentiation to correctly specify and maintain body cell types in the correct location. Notch ...
Plasmodium falciparum response to chloroquine and artemisinin based combination therapy (ACT) in Guinea-Bissau
(2009-11-06)
Plasmodium falciparum causes the most severe form of malaria and is the most common malaria species in sub-Saharan Africa. Chloroquine used to be the most common drug for the treatment of malaria. Due to development of ...
Studies on the regulatory roles of cholesterol and bile acids
(2007-05-04)
Cholesterol is essential for normal growth and development in mammals.
However, excess cholesterol can be harmful leading to diseases such as
atherosclerosis and gallstones. Once formed the ring structure of
cholesterol ...
Visualizing the dynamic interplay between the host and bacterial pathogen : a real-time study of renal infection
(2007-05-10)
The human body is a complex entity capable of handling a variety of
pathogenic challenges without developing disease symptoms. Sometimes,
however, the pathogens are superior and the host immune system is unable
to clear ...
Hemodynamics, echocardiography, and biomarkers in different heart failure phenotypes
(2020-02-12)
in cardiac output (+9.8 ± 21.6%; P = 0.026) and decrease in N-terminal pro-brain natriuretic peptide (-28.1 ± 16.3%, P < 0.001), estimated total peripheral resistance (-16.9 ± 18.3%, P = 0.004), and mean arterial pressure (-5.9 ± 8.2%, P = 0...
Notch in cancer and cancer metabolism : six degrees of intracellular turbulence
(2016-08-12)
Notch signaling is an evolutionarily conserved cell-to-cell contact-dependent signaling mechanism in multicellular organisms directing cellular fates both in early development and adult tissues. In metazoans the Notch ...
Dysregulated Notch signaling in breast cancer and liver disease
(2015-10-13)
The evolutionarily conserved Notch signaling pathway regulates crucial aspects of development and tissue homeostasis. This thesis contributes research towards understanding a role of non-canonical Notch signaling in the ...