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Adaptability of skeletal muscle to hormone treatment in relation to gender and aging
(1999-05-05)
The aims of this study were to investigate the expression of myosin isoforms, muscle contractility at the cell level, and changes in these parameters in response to altered hormonal status in aging male and female rodents. ...
Perioperative risk factors and outcomes
(2020-11-24)
Perioperative complications is an increasing issue worldwide, as surgical volume continues to grow. Myocardial and kidney injury, and myocardial infarction (MI), are known complications in non-cardiac surgery. Hemodynamic ...
Probing and pushing potential genetics, development and training of cognitive functions
(2012-05-15)
Capacities of cognitive functions increase considerably during childhood and adolescence. This development is of importance as poor development can predict lower performance on academic skills. Furthermore, severe impairment ...
Innate regulation of the adaptive immune system during autoimmunity
(2015-05-22)
Immune activation comprises multiple biological checkpoints to ensure proper
and regulated effector functions. Phagocytes such as macrophages, dendritic
cells and neutrophils have important functions during inflammation, ...
Effect of cycline-dependent kinase and matrix metalloproteinase inhibitors on hematopoietic and leukemic cells
(2008-10-24)
by roscovitine was consistent with apoptosis. Loss of mitochondrial membrane potential, release of cytochrome c, active fragment of caspase-3 and cleaved PARP were observed in all three cell lines, however, the pattern of activation of caspase-2 and -8 showed...
Prenatal nicotine exposure and effects on the health of the newborn
(2017-03-30)
Maternal smoking is one of the most important preventable risk factors in pregnancy. Whether it is nicotine or combustion products, or possibly both, that cause the adverse effects is not clear. The common substance in ...
Inflammatory proteins in the CNS-relation to Alzheimer's disease
(2005-05-18)
Most neurodegenerative disorders are characterised by an inflammatory process in the brain. Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common form of dementia in the elderly. Activated ...
Pharmacological targeting of nonsense mutant TP53 and PTEN in cancer
(2023-09-15)
The TP53 tumor suppressor gene encodes p53 and is inactivated by mutations in
around half of all human tumors. Approximately 11% of TP53 mutations are
nonsense mutations, resulting in the premature termination of translation ...
Exosomes : immunomodulators in cancer and therapy
(2016-08-30)
-specific T cells to the same extent as wild type exosomes. Even exosomes with MHC class I and II mismatch induced tumour-infiltrating CD8+ T cells and increase survival in a B16 melanoma model. This study provides new opportunities for the design of allogeneic...
Exosomes : the future of vaccination?
(2011-11-25)
of NKT cells subsequently amplified innate NK cell and γδ T cell responses as well as OVA-specific CD4+ T cell, CD8+ T cell and B cell responses. Our data suggest that exosome-induced antibody production is linked to subsequent activation of T follicular...