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Synovial sarcoma : a Scandinavian sarcoma group project
(1999-05-21)
changes in 35 of 69 tumor specimens. The frequency of aberrations/ tumor were higher in monophasic tumors than in biphasic. Gains of chromosome 8 were associated with large tumors (>5 cm). There was no obvious association between secondary aberrations...
Mechanistic insights into the biosynthesis of polyketide antibiotics
(2006-11-24)
Anthracyclines are a group of aromatic polyketide compounds with significant medical importance due to their antineoplastic properties. Doxorubicin and daunorubicin members of this family are among the two most commonly ...
Molecular epidemiology of tuberculosis
(2011-11-09)
Tuberculosis is a global epidemic, with one third of the world’s population estimated to be infected, around 9 million new active cases per year and close to 2 million deaths per year. Without adequate chemotherapy ...
Integrated assessment of environmental and human health risks of antibiotic residues and resistance for environmental and health policy
(2021-04-27)
Background: Antibiotic resistance is a global health crisis and a serious threat to progress in achieving the Sustainable Development Goals. This requires a One Health response that recognises the link between human and ...
Prognostic and predictive factors in Vietnamese breast cancer : a comparison with Swedish patients and effect on survival
(2012-03-07)
. The ER(+) rate was higher in premenopausal but lower in postmenopausal Vietnamese patients as compared to Swedish patients (71.1% vs. 58.4%, 44.7% vs. 71.6%, respectively). The PgR(+) tumors were found in 57.8% of pre- and 24.7% of postmenopausal...
Human colorectal cancer : experimental staging and therapeutics
(2007-04-06)
Colorectal cancer is the third most common cause of death in cancer
worldwide and approximately one million individuals are diagnosed yearly.
Surgery is the primary cure, and if that s not feasible, only palliative
therapy ...
Wnt/beta-catenin signaling in midbrain dopaminergic neurons
(2006-04-07)
Parkinson's disease (PD) is caused by a progressive degeneration of the dopaminergic (DA) neurons of the substantia nigra. However, the mechanisms underlying the degeneration remain elusive and there is no cure for P1) at ...
Nucleic acid in gene delivery and gene regulation
(2011-08-01)
The concept of gene therapy, initially attributed to a technology that would allow the correction of inherited genetic disease, has evolved over the years. The realization of the immense technical hurdles to achieve genetic ...
Resolving inflammation : analysis of mechanisms in relation to Alzheimer pathology and aging
(2021-08-10)
Alzheimer’s disease (AD) is the most common type of dementia, and its clinical symptoms are the reflections of pathological changes in the brain. The main pathological features of AD are intracellular aggregates of ...
Regulation of cellular degradation pathways by viral oncoproteins and microRNAs
(2020-10-08)
The cellular degradation system actively participates in cell homeostasis. Despite ongoing efforts and much progress in recent years, the underlying mechanisms of these pathways are not entirely understood. This thesis ...