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Experimental implant-associated orthopaedic infections
(1999-05-21)
Although indispensable in today's medicine, orthopaedic implants may also cause adverse reactions. A foreign body increases the local susceptibility to colonisation by microorganisms, and hence the risk of infections. These ...
Measures to prevent microembolization in cardiac surgery and during angiography with special reference to carbon dioxide
(2020-02-21)
Background: Cardiovascular interventions including open heart surgery using cardiopulmonary bypass (CPB) and coronary angiography may introduce air and particulate arterial embolism that may lead to tissue lesions of the ...
Radiotherapy in advanced head and neck cancer
(2023-03-17)
Head and neck cancer (HNC) is a group of malignant tumours located in the mucosa of the upper aero-digestive tract. The location of the tumour, close to several critical organs, can often result in great suffering for the ...
Outcome of gastric cancer surgery in Sweden
(2020-05-20)
Gastric cancer worldwide is the fifth most common cancer and has the third highest cancer related mortality. Curative treatment includes surgical resection but comes with risk of complications and the optimal surgery ...
Cisplatin-induced tumor cell death signaling and potentiation by energy metabolism inhibitors
(2007-01-05)
Treatment of cancer is associated with challenges including the tumor development of resistance. By elucidating intracellular signal transduction pathways elicited by therapy it is possible to identify structures and ...
Chromatin remodelers and their roles in chromatin organization
(2012-11-20)
The DNA in the eukaryotic nucleus is organized into a complex DNA-protein structure called chromatin. The basic repeating unit of chromatin is the nucleosome, which consists of 147 bp of DNA wrapped around a histone protein ...
Novel approaches for cancer immunotherapy
(2008-05-22)
-TAMs can be also modified using zoledronic acid (ZA). We show that ZA suppresses the expression of MMP-9 by TAMs and, in combination with IL-12, enhances their tumor-eliminating functions. Furthermore, ZA drives the proliferation and activation of gamma...
Deciphering HIV genetic variability and evolution by massive parallel pyrosequencing and bioinformatics
(2014-05-05)
HIV-1 is a virus with a very variable genome and therefore has the ability to adapt to new environments which include escape from immune pressure and suboptimal antiretroviral treatment. Next-generation sequencing (NGS), ...
Plasmodium falciparum drug transporter genes in emerging malaria multidrug resistance
(2011-03-24)
Malaria is caused by an intracellular protozoan parasite of the genus Plasmodium. The use of chemotherapy, the foremost tool available for the control of the disease, has been challenged in the last decades by the development ...
Brain imaging in extremely preterm infants : relations to perinatal factors and outcome
(2014-01-03)
The survival of extremely preterm infants has improved over the last decades along with the advances in perinatal care. These immature children are born at a vulnerable stage of brain development, before entering the third ...