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Type IV collagen : regulation of COL4A1 and COL4A2 genes and gene therapy of Alport syndrome
(1999-05-07)
Type IV collagen is an important structural protein in basement membranes, which am thin sheet-like structures located between organized tissues and the connective tissue. Type IV collagen is composed of six genetically ...
Attempted suicide and shame
(2012-02-02)
A suicide attempt constitutes not only a risk factor for suicide, but also an expression of human suffering. As therapists, physicians and caring personnel we have an opportunity to reach out to this suffering individual ...
Complications following anterior cruciate ligament reconstruction
(2021-02-16)
Background: Venous thromboembolism (VTE) and septic arthritis (SA) are two rare complications following anterior cruciate ligament reconstruction (ACLR). Due to their rare incidence, risk factors and outcome are difficult ...
Effects of chemotherapy on bone growth and chondrocyte cell death signaling
(2010-11-01)
of dexamethasone-induced growth retardation. By investigating these mechanisms, we found that dexamethasone activates caspase-8, -9 and -3 in proliferative chondrocytes. In addition, the Akt-PI3K signaling pathway, which plays a key role in the survival...
Hsp70 in immunotherapy : a potential vector in cancer and viral vaccines
(2000-04-28)
by CD8+ T cells, as depletion of CD4+ T cells or using T cells from CD4-/- mice showed the same pattern of tumour recognition. Hsp70 was purified from MC tumours or from liver tissue and used to immunise mice. Upon challenge with live tumour cells...
Toxicity and biocompatibility of nanoparticles, and studies on oxidative stress and DNA damage
(2015-05-11)
Oxidative stress is associated with several diseases, either as a cause or a consequence.
Chronic kidney disease (CKD) is one example of a disease in which elevated levels of
oxidative stress are frequently reported. ...
Physical workload in surgery : from risk assessments to interventions
(2022-05-20)
Surgeons often suffer from work-related musculoskeletal disorders (WMSDs), with the neck, shoulders, and low back being the most affected body sites. Among other factors, the high physical workload has been recognized as ...
Influenza specific T- and B-cell responses in immunosuppressed patients
(2015-04-15)
restricted CD8 T-cells were enumerated over the course of a natural pandemic influenza infection and Pandemrix® vaccination in a prospective study reported in Paper IV. PBMCs from vaccinated control individuals exhibited a significantly increased percentage...
Intravenous access in distressed children : effects of midazolam and nitrous oxide on success rate, hormone and metabolic stress responses
(2011-04-29)
Background and Aims: Intravenous (IV) access has demonstrated high levels of pain and distress in children. A stress full IV access should be avoided, primarily by the children, but also for the parents and staff. When ...
Statistical models of breast cancer tumour progression for mammography screening data
(2018-09-17)
In this thesis we propose a novel statistical natural history model and illustrate how it can be applied to epidemiological breast cancer screening data to increase knowledge about how breast cancers progress over time and ...