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T cell antigen receptor usage, phenotype and cytokine production in human diseases
(1999-04-16)
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In allergic alveolitis most patients had lung-restricted CD8+ expansions of T cells using particular V[alpha] or V[beta] segments. These expansions, some of which were dramatic, normalized with clinical improvement. Similarly, patients with allergic asthma...
Drug discovery targeting non-amyloid pathways in Alzheimer’s disease
(2020-04-02)
Alzheimer’s disease (AD) is the most common form of dementia with almost 50 million people affected and unfortunately, no cure or treatment to halt the disease progression is available. In the hereditary forms of AD, an ...
Musculoskeletal injuries and generalized joint laxity in ballet dancers
(2012-09-13)
. In study II, the ballet dancers were found to have a less prominent thoracic kyphosis, lumbar lordosis, and showed a higher incidence of joint mobility. In Study III, the injury incidence was 0.8/1,000 hours of activity and the injury incidence tended...
On the children's global assessment scale (CGAS)
(2012-02-29)
Rating scales and diagnostic instruments have become increasingly important tools in psychiatric care over the past several decades. Using these standardized tools to collect information and evaluate patients enables ...
Endothelial dysfunction in atherosclerosis and type 2 diabetes : clinical and molecular studies of the role of endothelin and arginase
(2018-05-08)
Background: Atherosclerosis is a modern world scourge and the number of people worldwide diagnosed with type 2 diabetes (T2D) is on the rise, causing much morbidity and mortality. Endothelial dysfunction (ED) is an early ...
Stable high-sensitivity cardiac troponin T levels and outcomes
(2018-11-15)
Background: Many patients who seek medical attention because of chest pain in the emergency department (ED), without myocardial infarction (MI) as a final diagnosis, will have cardiac troponin (cTn) levels above the upper ...
Determinants of hearing impairment in Swedish hunters : an e-epidemiological approach
(2016-04-08)
Background: 290 236 persons bought a hunting license in Sweden 2014/15. Hunters are
spread all over the country and come from all socioeconomic groups. Recreational fiearms
can produce peak noise levels between 156-164 ...
von Willebrand disease in women : heavy menstrual bleeding and obstetrical bleeding
(2018-09-25)
Von Willebrand disease is the most common inherited bleeding disorder worldwide with a prevalence, reaching 1% of general population. vWD is equally distributed between genders. However, vWD-affected females experience ...
The role of SOXC transcription factors in B-cell development and lymphoid malignancies
(2017-09-15)
Mantle cell lymphoma (MCL) accounts for 5-10% out of all Non-Hodgkin lymphomas (NHLs) and is one of the most aggressive forms of lymphomas with a median survival of less than 5 years. Currently, MCL is considered to be an ...
Novel insights into dishevelled and frizzled function
(2018-10-18)
The formation of a multicellular body during embryonic development is one of the most fascinating processes in biology. The cells are in constant communication and must be precisely coordinated. Several essential signalling ...