Search
Now showing items 1-10 of 21
Mechanisms and mediators of apoptosis : with special reference to hematological disorders
(1999-04-08)
Life and death are inextricably entwined. Naturally occurring cell death or apoptosis is essential for the of homeostasis and serves to remove extraneous or dangerous cells in a swift and unobtrusive manner. work has ...
Role of dolichyl phosphate, N-linked glycosylation and cell membrane expression of insulin-like growth factor-1 receptor in maintenance of malignant cell growth
(1997-11-20)
Several studies have demonstrated that mevalonate (MVA) synthesis is required for cell proliferation. The mechanisms underlying MVA-regulated cell growth are still not fully understood. One conceivable mechanism for ...
What can genetically informative designs add to the understanding of ADHD?
(2016-02-23)
Attention-deficit/hyperactivity disorder (ADHD) is a highly prevalent and clinically
heterogeneous neurodevelopmental disorder affecting approximately 3.4–7.3% children and
adolescents and 2.5–3.4% adults worldwide, ...
Tissue microbiology : an integrated approach for intravital studies of host-pathogen interactions
(2017-05-08)
A bacteria infection in the living host is the summation of a myriad of interactions. Reductionistic and sacrificial experiment models cannot replicate this complexity. The Tissue Microbiology approach overcomes this by ...
Genetic, epigenetic and environmental factors of importance for CYP1A2 catalyzed drug metabolism
(2008-11-14)
The heme containing cytochrome P450 (CYP450) enzymes participate in the phase I metabolism of drugs and other xenobiotics as well as endogenous substrates. CYP1A2 is one of the major CYP450 enzymes and account for about ...
Analysis of phenotype reversibility in Hutchinson-Gilford progeria syndrome in mice
(2017-04-12)
Aging affects all people and is a complex process involving both genetic and environmental factors in a way that is not yet completely understood. Studies of premature aging syndromes might be helpful to acquire further ...
Pathophysiological factors and genetic association in endometriosis
(2011-01-27)
Introduction: Endometriosis is a common benign gynecological disease where endometrial tissue forms lesions outside the uterine cavity. Endometriosis is estimated to affect about 10% of women of reproductive age, rising ...
Characterization of HIV-1 in the central nervous system during suppressive therapy
(2013-08-12)
Combination antiretroviral therapy (cART) is effective in suppressing HIV-1 RNA levels below the lower-limit of detection of clinical assays (<20-50 copies/mL) but is not curative and more sensitive assays can detect very ...
On the immunopathogenesis of HIV infection
(2006-08-25)
CD8+ T-cell dependent clearance of microbial infections by perforin mediated killing of infected cells is a central component in the combat against viral infections. In HIV-1 infected individuals the incidence of virus infected cells in lymphoid...
In vitro studies on anti-leukemic effects of tetracycline's analogues and cyclophosphamide
(2015-05-25)
Leukemia is a heterogeneous group of hematological malignancies that originate from the bone marrow. Leukemias are classified as acute or chronic. Although acute leukemia affects patients of all ages, acute lymphoid leukemia ...