Search
Now showing items 1-10 of 28
Interaction between gastric pathogen Helicobacter pylori and host cells
(1999-08-09)
to viable versus fixed AGS cells was not significantly different. The observation that chloramphenicol, an inhibitor of bacterial protein synthesis and cycloheximide, an inhibitor of eukaryotic protein synthesis, significantly reduced adherence of type 1...
Adenosine A2A receptors : characterization, localization, G protein coupling and interactions with dopamine D2 receptors
(2000-02-18)
Adenosine not only has a role in cellular energy metabolism but is recognized as an intercellular messenger with an important function in physiology and pathophysiology. It exerts its effects via a family of G protein ...
Epidemiology, risk and protective factors of self-immolation : a study from Iran
(2013-04-04)
Background: Suicide by self-burning (self-immolation) is one of the suicide methods that is far more common in low-middle income countries than in high-income ones. Iran is one of the countries that has a high rate of ...
Oxygen-dependent regulation of HIF-1alpha expression and function
(2009-09-04)
that mediate adaptive cellular responses to hypoxia by activating the transcription of target genes. HIF is a heterodimer consisting of an oxygen-regulated alpha subunit and a constitutively expressed HIF-1beta (ARNT) subunit. Both HIF subunits belong to the b...
Genetic studies in familial non-BRCA breast cancer
(2017-11-09)
Family history is an important risk factor for breast cancer, the presence of breast cancer in a first degree relative in general nearly doubles the risk and the risk increases with the number of affected relatives. Pathogenic mutations in BRCA1...
Mathematical modelling of insulin signalling : effects on glucose metabolism in skeletal muscle
(2010-04-13)
The use of models to understand complex phenomena is indispensable to the
scientific community. The advantage of a model is that it simplifies the
phenomena under study. However, a model should be only as complex ...
Generation and investigation of neural microenvironment in health and disease
(2019-10-09)
neural stem cells (NSCs). By applying different metabolic conditions in vitro, we showed that hypoxia and 2-Deoxy-D-glucose increased acetylation of CtBP2 in proliferating NSCs. Additionally, 1% oxygen treatment resulted in altered homodimerization of Ct...
Depression in youth and adults : etiology, outcomes, and comorbidities
(2022-02-02)
to the co-occurrence of depression and endocrine-metabolic conditions, which was primarily due to genetics for non-autoimmune conditions, and to unique environmental factors for autoimmune disorders, especially for type 1 diabetes. These findings expand...
Cardiovascular comorbidity in rheumatoid arthritis
(2010-10-29)
diabetes mellitus and its relationship to rheumatoid arthritis using a population-based case-control study of rheumatoid arthritis. 1,419 patients with newly diagnosed rheumatoid arthritis and 1,674 age-, sex-, and residential area- matched controls were...
Pharmacological and analytical studies of the cyclin dependent kinase inhibitors
(2009-10-30)
, glomerulonephritis and inflammatory diseases. (R)-roscovitine (Rosco) is a synthetic tri-substituted purine that inhibits selectively Cdk1, 2, 5, 7 and 9. Rosco has shown promising cytotoxicity in cell lines and tumor xenografts. Rosco so far has only demonstrated...