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Periodontal disease in adolescents with Down syndrome
(1999-03-19)
Characterization of virulence factors in P. falciparum malaria is essential in order to identify new therapeutic and prophylactic targets. Rosette formation, the binding of uninfected red blood cells to parasite-infected ...
Deciphering microglia plasticity in glioma
(2019-01-11)
Microglia are the innate immune cells of the brain. One of the main characteristics of microglia is its extremely plasticity, which is necessary for them to deal with changing circumstances. Activation of microglia can ...
Chromatin remodelers and their roles in chromatin organization
(2012-11-20)
The DNA in the eukaryotic nucleus is organized into a complex DNA-protein structure called chromatin. The basic repeating unit of chromatin is the nucleosome, which consists of 147 bp of DNA wrapped around a histone protein ...
Regulation of eukaryotic cell physiology using organic bioelectronics
(2011-03-25)
The field of organic bioelectronics deals with the implementation of conducting polymer science in biology and medicine. The purpose of this thesis was to develop organic bioelectronic devices for the regulation of eukaryotic ...
Elucidating regulatory elements : studies in chronic lymphocytic leukemia and multiple myeloma
(2018-12-21)
With next generation sequencing taking center stage in genetic and epigenetic research, its applications and challenges are many. This work revolves around the application of bioinformatics in different contexts: basic ...
Modulation of HIV immune responses in natural infection and after genetic immunization
(1999-09-14)
Identification and treatment of HIV-1 infection are both urgent, in view of the continued spread of the infection. We developed easy and inexpensive serological methods for the diagnosis and follow-up of children born to ...
Ready to pull : force transmission during vascular development
(2019-12-17)
The transmission of mechanical forces controls a multitude of cellular processes such as migration, the formation of new organs, muscle contraction, and resistance to the continuous stress that blood flow exerts on the ...
Customization of tamoxifen therapy : not only a dream
(2011-09-06)
Breast cancer (BC) is the most common form of cancer in western women. The grand majority of the afflicted women are eligible for endocrine treatment. Tamoxifen has been the golden standard treatment for more than three ...
Studies on novel interactors in human adipose tissue
(2011-05-19)
Obesity is associated with a mild inflammation and altered protein secretion in adipose tissue. These changes have been suggested to contribute to the development of obesity-associated disorders including, insulin resistance, ...
Effect of cycline-dependent kinase and matrix metalloproteinase inhibitors on hematopoietic and leukemic cells
(2008-10-24)
Rapid advances in molecular and cellular biology have improved the understanding of the mechanisms involved in leukemia development. Cyclin-dependent kinases (CDKs) and matrix metalloproteinases (MMPs) have been suggested ...