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Pathomechanism of diabetic nephropathy
(1999-01-29)
Diabetic nephropathy is today the most common cause of end stage renal failure. The risk for developing overt diabetic nephropathy is considerably reduced by antihypertensive treatment, and adequate control of blood glucose. ...
The role of estrogen receptors in the auditory system
(2011-12-21)
Both laboratory and clinical studies have previously demonstrated estrogenic effects on auditory function. The overall scope of this study was to investigate the physiological and molecular involvement of estrogens and ...
Chemokine receptor expression and function in experimental autoimmune neuroinflammation
(2007-05-25)
and CCR5 are prerequisite for controlling the migration of monocytes/macrophages into inflammatory foci. The role of fractalkine (CX3CL1) and its receptor CX3CR1 in the CNS is more unclear, but their expression pattern suggests a role in neuron...
Endothelial dysfunction in atherosclerosis and type 2 diabetes : clinical and molecular studies of the role of endothelin and arginase
(2018-05-08)
Background: Atherosclerosis is a modern world scourge and the number of people worldwide diagnosed with type 2 diabetes (T2D) is on the rise, causing much morbidity and mortality. Endothelial dysfunction (ED) is an early ...
Host-microbe interactions in coxsackievirus infection : focus on innate immunity
(2010-05-28)
Coxsackievirus group B (CVB) is a common virus that usually causes only
mild symptoms in humans. However, occasionally these infections result in
severe diseases like meningitis, myocarditis and pancreatitis. In
addition, ...
Determinants of hearing impairment in Swedish hunters : an e-epidemiological approach
(2016-04-08)
Background: 290 236 persons bought a hunting license in Sweden 2014/15. Hunters are
spread all over the country and come from all socioeconomic groups. Recreational fiearms
can produce peak noise levels between 156-164 ...
Redesigning an emergency department for interprofessional teamwork : a longitudinal evaluation of the impact on patient flow and team behaviour
(2020-05-19)
for the teamwork period, 228 minutes (95% CI: 226.4 to 230.5) compared to 232 minutes (95% CI: 230.8 to 233.9) for the nurse-led triage period, and longest for the physician-led triage period, 250 minutes (95% CI: 248.5 to 252.6). The adjusted ED length of stay...
Studies of stem cell and adhesion proteins in breast cancer
(2014-10-06)
Breast cancer is the commonest cancer and second leading cause of cancer death in women. It has been shown that breast cancer tumorigenic/stem cell like cells are CD24-/low CD44+EpCAM+. These cells constitute less than 5% of the cells within a...
Survival after different forms of bystander cardiopulmonary resuscitation in out-of-hospital cardiac arrest : ‛to breathe or not to breathe?’
(2019-10-31)
: In Study I we assessed survival after CPR prior to EMS arrival compared to no CPR prior to EMS arrival. Witnessed OHCA in 1990-2011 were included (N = 30 381). CPR prior to EMS arrival was performed in 51 % of all cases. Survival to 30 days was 10.5...
Epidemiological studies of vacuum extraction delivery : incidence, risk factors and subsequent childbearing
(2014-11-10)
The aim of this thesis was to bring focus on factors and outcomes associated with vacuum
extraction delivery (VE). Delivery by VE is associated with both maternal risks (such as
obstetric anal sphincter ruptures, postpartum ...