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Hypoxia and auto resuscitation in the neonatal rodent with special reference to the sympatho-adrenal system
(1999-01-04)
Preterm infants exhibit irregular breathing with frequent episodes of apnea, which may be associated with cyanosis and bradycardia. Perinatal asphyxia causes a considerable amount of morbidity and mortality that occurs ...
Regulatory function of homeobox genes in the development of C. elegans
(2010-09-10)
, ceh-6, ceh-26, ttx-1 and ceh-37, in the excretory cell development. We showed that the POU-III class homeobox gene ceh-6, the Prospero class homeobox gene ceh-26, and two otd/Otx family homeobox genes, ceh-37 and ttx-1 formed a regulatory hierarchy...
Exploring the role of mesenchymal stromal cells in endometriosis
(2018-11-16)
Endometriosis is a chronic inflammatory disease where there is growth of endometrial tissue in ectopic sites, most commonly within the pelvic cavity. The major symptoms of this disease are chronic pelvic pain and infertility. ...
Epstein-Barr virus and genomic instability : a new look at the mechanisms of viral oncogenesis
(2010-12-20)
EBV is associated with a variety of lymphoid and epithelial malignancies but the mechanisms of oncogenesis are still not fully understood. The aim of the work described in this thesis was to assess whether induction of ...
Blocking interleukin-1 signalling in the brain-structural and functional outcomes
(2008-10-07)
to hsIL-1ra, and analysed the behavioural profile at the ages of 6 and 12 months, as well as the morphology of the brain at 12 months of age. Multivariate data analysis was used for detecting significant separation according to the genotype (WT vs. Tg hs...
Tumor acidosis in malignant progression and therapy
(2016-04-06)
H. Finally, we developed a model of drug screening performed on cancer cells chronically adapted to pH 6.8 in order to identify compounds targeting cells in metabolic stress conditions. We identified Verteporfin as a promising new anticancer drug able...
Genetic and metabolic studies towards personalized conditioning regimen prior to stem cell transplantation
(2014-08-11)
Hematopoietic stem cell transplantation (HSCT) is a curative treatment for several malignant and non- malignant diseases. The busulphan (Bu)/cyclophosphamide (Cy) combination is one of the most common conditioning regimens ...
Investigating the role of p73 proteins in controlling the tumor microenvironment
(2020-10-20)
Cancer is a multifactorial disease governed by oncogenes and tumor suppressors that not only impact on the behavior of the cancer cells but also influence many processes in the surrounding tumor microenvironment. The most ...
Epidermal stem cells at the point of no return
(2023-05-17)
The skin is our main barrier against outside harm, and it helps to maintain internal
homeostasis. These functions are mostly fulfilled by the epidermis, which is the
outermost layer of the skin, formed from keratinocytes ...
Immunoregulatory effects of placenta-derived decidual stromal cells
(2016-01-08)
DSC treatment. Increased plasma concentrations of IL-6, IL-8, and IP-10 distinctly differentiated the non-responders from the responders before DSC intervention. Although the expression of HLA-DR decreased over time in the CD4+ compartment...