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Regulation of glucose transport and insulin-stimulated GLUT4 translocation in skeletal muscle
(1998-11-20)
was unaffected by insulin. In isolated rat skeletal muscle, acute exposure to hyperglycaemia resulted in increased rates of glucose transport. Dantrolene, an inhibitor of Ca2+ release from the sarcoplasmic reticulum blocked the hyperglycaemia effect on glucose...
p53 guardian of the genome and target for improved treatment of leukemia
(2007-03-02)
P53 acts in several cellular processes as cell cycle checkpoints, DNA
repair senescence and the surveillance of genomic integrity. Wt p53
inhibits cancer processes by causing cell cycle arrest and apoptosis. P53
is ...
Art of tumor immunity : extricating hypoxia-driven immunosuppression in the solid tumor microenvironment
(2023-09-20)
main effector cytotoxic cells, Paper I examined how targeting the adenosine (ADO) signaling axis via adenosine-2B receptor (A2BR) restore T cell function and Paper II investigated the influence of pseudohypoxia on NK cells using clear cell renal cell...
Integrated assessment of environmental and human health risks of antibiotic residues and resistance for environmental and health policy
(2021-04-27)
Background: Antibiotic resistance is a global health crisis and a serious threat to progress in achieving the Sustainable Development Goals. This requires a One Health response that recognises the link between human and ...
Hemodynamics, echocardiography, and biomarkers in different heart failure phenotypes
(2020-02-12)
in cardiac output (+9.8 ± 21.6%; P = 0.026) and decrease in N-terminal pro-brain natriuretic peptide (-28.1 ± 16.3%, P < 0.001), estimated total peripheral resistance (-16.9 ± 18.3%, P = 0.004), and mean arterial pressure (-5.9 ± 8.2%, P = 0...
Aspects of locally advanced colon cancer
(2022-09-15)
University Hospital between 2007 and 2014 were included (n=121). Malignant invasion in resected tissues were found in 77 patients and inflammatory adhesions were found in 44 patients. The proportion of radical (R0) resections was 91% in patients with tumor...
Regulation of cellular responses to hypoxia by HIF-1alpha-dependent and -independent signaling pathways
(2012-08-13)
of the Hes1 promoter are critical for hypoxia-inducible transcriptional regulation of Hes1 promoter activity. In paper III, we investigated the molecular mechanism of β-cell death triggered by hypoxia. We show that apoptosis induced by exposure to 1% O2...
Perks and considerations when targeting functional non-coding regions with CRISPR/Cas9
(2023-05-12)
Since the CRISPR system was discovered as an adaptive immune response in prokaryotic cells, the past decade has witnessed the engineering and deployment of CRISPR/Cas9 as one of the most efficient and powerful molecular ...
Hantaviruses, escapees from the death row : viral mechanisms towards apoptosis resistance
(2019-10-25)
Over the past decades, humanity has witnessed a constant stream of emerging pathogenic RNA viruses. The recurrent outbreaks of Ebola virus in Africa, the emergence of West Nile virus in North America and the sporadic but ...
Who is killing whom? Hantaviruses vs programmed cell death
(2016-02-17)
Hantaviruses belong to the Bunyaviridae family of negative stranded RNA viruses. They
carry a tri-segmented genome and consist of four structural proteins. The four structural
proteins are two glycoproteins Gn and Gc, a ...