Search
Now showing items 1-9 of 9
Validity and reliability of vehicle collis : crash pulse recorders for impact severity and injury risk assessment in real-life frontal impacts
(1998-11-25)
The general objectives of this thesis were to study the importance of valid and reliable data from real- life collisions, especially the effects of inaccurate data on analyses of eg injury risks. Furthermore an objective ...
Cellular mechanisms of human muscle fatigue and disease-related loss of muscle function
(2020-08-27)
A loss of skeletal muscle function and mass is a hallmark of several diseases resulting in a dismal life quality and poor prognosis. Impaired intracellular Ca2+-handling has been proposed as an underlying cause of these ...
Immunological alterations, therapies with immune check-point inhibitors and beyond in patients with metastatic melanoma
(2020-10-07)
-derived suppressor cells (MDSCs) during treatment. It was also observed that CD8+ effector memory T cell frequencies at the end of treatment were higher in patients with clinical benefit and correlated with longer survival. In addition to this, it was observed...
Immunological and clinical long-term effects of idiotype vaccination in multiple myeloma patients
(2007-02-22)
In spite of the promising results shown by new anti-myeloma agents,
multiple myeloma (MM) remains incurable and additional therapy to
overcome the inevitable disease recurrence is greatly needed.
Immunotherapy is currently ...
Potential overtreatment during life-limiting illness and end of life in older adults
(2023-10-11)
(RRtertiary education: 0.89 [0.81-0.98]), and multi-dose drug dispensing (RR: 1.22 [1.13-1.32]). Initiation of treatment was associated with, for instance, number of hospitalised days (RR1-14 inpatient days: 1.81 [1.12-2.91]) and CDK4/6 use (3.16 [2.25- 4...
Therapeutic response in human cancers : the dual role of STAT signalling
(2016-08-08)
STAT proteins were discovered as the mediators of interferon (IFN) signalling in response to viral infections. Later, it has become evident that STATs are activated by many stimuli and that they exert multifaceted effects ...
Intimate partner violence among women of reproductive age in Nigeria : magnitude, nature and consequences for reproductive health
(2011-01-05)
Background: Intimate Partner Violence (IPV) against women is now recognised as a problem of global magnitude, owing to its detrimental consequences on the health, social and economic welfare of women and their children. ...
Characterization of dengue virus isolates from patients experiencing dengue fever, dengue hemorrhagic fever, and dengue shock syndrome
(2011-11-21)
The four serotypes of dengue virus (DENV) belong to the genus flavivirus, and have a positive sense, single-stranded RNA genome of ~11 kb. The DENVs cause the most common arthropod-borne viral disease in man with ~100 ...
Experimental spinal cord injury : methodological and neuroimmunological contributions with some historical background
(2011-01-19)
methylprednisolone administration within 8 hours postinjury oftentimes accompanied by neurosurgical interventions. As a rule, SCI becomes a chronic condition with significant handicap for the patient and socioeconomic repercussions for the affected families...