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Mechanisms of opiate tolerance and dependence in the rat
(1998-11-20)
Drug addiction is a complex phenomenon with various biological, psychological and social causes and consequences, which belongs to the major problems of today's society. Opiates have been used and misused for thousand of ...
A clinical epidemiological study on end-stage liver disease in Ghana
(2022-06-01)
End-stage liver disease (ESLD), including advanced liver cirrhosis and hepatocellular carcinoma (HCC), is the final stage of long-standing injury to the liver due to risk factors such as chronic viral hepatitis and alcoholic ...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...
Predicting and monitoring disease course in rheumatoid arthritis : imaging, biomarkers, risk factors, and integrative medicine
(2017-04-28)
Rheumatoid arthritis (RA), the most common inflammatory arthritis, is a chronic, potentially debilitating autoimmune disease that can lead to functional disability, bone erosion, and chronic pain. The modern era of treatment ...
Pleiotropic effects of HMG-CoA reductase inhibitors : studies in vitro and in vivo
(2012-08-09)
Cardiovascular disease (CVD) is the prime cause of death in industrialized countries, resulting from the progression of atherosclerotic lesions. An increased level of plasma cholesterol, particularly within low-density ...
Antibody-associated inflammation in and outside the joint in rheumatoid arthritis
(2017-08-17)
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by pain, chronic inflammation and joint destruction. Epidemiological investigations in large populationbased cohorts have identified both genetic ...
The burden of back pain : evaluation of costs and health outcomes
(2020-11-27)
). There were no statistically significant differences when physiotherapy, chiropractic care, and combination treatment were compared with advice, over a 6-month period, in the treatment of patients with CLBP in Sweden. Due to a high dropout rate and low power...
Host-microbe interactions in coxsackievirus infection : focus on innate immunity
(2010-05-28)
Coxsackievirus group B (CVB) is a common virus that usually causes only
mild symptoms in humans. However, occasionally these infections result in
severe diseases like meningitis, myocarditis and pancreatitis. In
addition, ...
Molecular and epidemiological investigations of lung involvement in very early rheumatoid arthritis
(2015-11-26)
of ACPA-positive patients. Using mass spectrometry we were able to identify two novel citrullinated vimentin peptides that were present in a majority of bronchial (n=6) and RA synovial biopsies (n=7) tested. Immune reactivity against these targets...
Amino acid predictors of HIV-1 coreceptor use in different subtypes and their application to antiretroviral treatment
(2014-01-10)
The human immunodeficiency virus type 1 (HIV-1) group M is responsible for the HIV pandemic and has great genetic variability. The main subtypes and circulating recombinant forms belonging to this group differ in their ...