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Gene expression during hard tissue formation
(1998-11-27)
The purpose of this thesis was to study the formation of the extracellular matrix (ECM) of bone and dentin during development. Molecular techniques, such as in situ hybridization and RT-PCR, were used to investigate the ...
Endemic ataxic polyneuropathy in Nigeria
(2002-03-22)
of ataxic polyneuropathy in Ososa was 63 per 10 000 personyears, 27 for males and 93 for females. The adjusted odds ratios (95 % CI) were 0.44 (0.09 2.26) for the intake of cassava foods, and 1.74 (0.48- 6.28) for exposure to cyanide. The concentrations...
Identification and characterization of candidate genes for type 2 diabetes in the GK rat
(1999-11-10)
Type 2 diabetes is a common multifactorial disorder with complex genetics, which presents with a heterogeneous clinical phenotype as a result of interaction between genetic susceptibility and environmental risk factors. Hence, the search...
Pediatric acute neuropsychiatric syndrome : diagnosis, biomarkers and treatment
(2019-05-23)
Background: Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS) and Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) are proposed diagnoses combining a clinical picture ...
Emergency department crowding and hospital patient flow : influential factors and evidence-Informed solutions
(2016-09-06)
minutes [CI: 38 to 65]. Physician initial assessment duration (PIAD) decreased by 53 minutes [CI: 48 to 57]. The MDRNSTAT-associated shifts’ leftwithout- being-seen rate was 1.5% versus 2.2% for the control (p=0.06). No patients returned to the emergency...
Cellular mechanisms of human muscle fatigue and disease-related loss of muscle function
(2020-08-27)
A loss of skeletal muscle function and mass is a hallmark of several diseases resulting in a dismal life quality and poor prognosis. Impaired intracellular Ca2+-handling has been proposed as an underlying cause of these manifestations. This thesis...
Cortical plasticity in response to median nerve trauma
(2016-11-11)
Median nerve injuries in adults, repaired with nerve suture, lead to incomplete functional recovery despite improved surgical technique. This results in a reduction in quality of life, poorer working ability and a considerable ...
Function, expression and polymorphism of human alcohol dehydrogenase 3/glutathionedependent formaldehyde dehydrogenase
(2001-05-02)
in an ADH1 enzyme through the generation of the double mutant ADH1C2Leu57Asp/Aspll5Arg. This was partly successful since ADH3-like kinetic features for 12hydroxydodecanoate and ethanol was monitored. However, the ADH1C2Leu57Asp/Asp115Arg displayed no HMGSH...
Leukotriene A4 hydrolase : identification of amino acid residues involved in catalyses and substrate-mediated inactivation
(2001-09-14)
Leukotriene (LT) A4 hydrolase catalyzes the committed step in the
biosynthesis of LTB4, a classical chemoattractant and immuine-modulating
lipid mediator involved in inflammation, host-defense against infections,
and ...
Primary structure, expression and function of laminin [alpha]4
(2000-11-10)
]2, [alpha]3 and [alpha]5 did not affect binding. Considering the expression patterns of laminin-8 and integrin [alpha]6[beta]1 it is likely that the former is a ligand for the latter in vivo as well. Platelets were found to contain laminin-8...