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Influence of extrinsic factors on bone scintigraphy an experimental and clinical study
(1997-10-30)
Bone scintigraphy takes advantage of the strong affinity of technetiated diphosphonates to bone. These compounds accumulate particularly at sites of new bone formation which occurs as a response to various conditions ...
Aspects on extracorporeal life support for severe acute respiratory failure with special reference to the influenza A/H1N1 2009 pandemic
(2016-11-03)
Extracorporeal membrane oxygenation provides pulmonary and circulatory support. First abandoned from the majority of the intensive care community because of disappointing results in several trials (with questionable methods), ...
Fat mass, adipokines and clinical complications of chronic kidney disease
(2006-05-26)
Patients with chronic kidney disease (CKD), irrespective of initial etiology, have a risk of cardiovascular morbidity (CVD) and mortality that is many-fold higher than that of a similar person without CKD. While traditional ...
Mechanisms controlling midbrain dopaminergic neuron development
(2016-11-25)
causes the loss ofLmx1a and Ngn2 expression in the midbrain floorplate resulting in the loss of mDA progenitor specification and neurogenesis in this region. Only a few ectopic LMX1A+, NURR1 + and TH+ cells were transiently found in the basal plate...
Radiomics in cancer prognosis : applications and limitations of quantitative texture analysis
(2018-11-16)
Medical imaging has become an integral part of clinical diagnostics since the discovery of X-rays at the end of the 19th century. Recent advances in computing power have opened up the possibility to extract quantitative ...
L-DOPA-induced signaling pathways and neuroepigenetic mechanisms in experimental parkinsonism and dyskinesia
(2014-11-07)
monophosphate (cAMP)/cAMP-dependent kinase (PKA)/ dopamine- and cAMP-regulated phosphoprotein of 32 kDA (DARPP-32) pathway. This exaggerated response results in excessive activation of the downstream extracellularregulated kinases 1 and 2 (ERK1/2) and mammalian...
The next level : video gaming, cognition and motivation in surgical simulator training
(2015-05-08)
Image guided surgery uses small incisions or existing entry ports of the body in order to
decrease surgical trauma which will hopefully lead to less infections, complications and
number of days needed in the hospital. ...
Integrated assessment of environmental and human health risks of antibiotic residues and resistance for environmental and health policy
(2021-04-27)
Background: Antibiotic resistance is a global health crisis and a serious threat to progress in achieving the Sustainable Development Goals. This requires a One Health response that recognises the link between human and ...
A multi-omics approach to uncover estrogen receptor (ER) and activator protein 1 (AP-1) signaling networks in breast cancer
(2019-09-27)
significant reduction in cell proliferation in response to E2 compared with vehicle, conversely, only ERα-expressing MCF7 cells displayed an increased cell proliferation upon E2 treatment. The RNA-seq results indicated that ERβ could modulate specific gene...
Screening for atrial fibrillation in high-risk individuals : a stroke preventive effort
(2016-10-31)
control group or to attend a screening study. Of the 13,331 individuals who were invited, 7,173 (54%) participated. New AF was detected in 218 participants (3.0 %, 95% confidence interval (CI) 2.7-3.5) using twice daily intermittent ECG recordings for 14...