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Cholinesterase inhibitors in Alzheimer's disease : an experimental study on mechanisms of interatcion with muscarinic and nicotinic receptors and neuroprotection
(1997-10-31)
transfected fibroblast cell line, stably expressing the major neuronal nAChR subtype a4B2, was utilized as a model system. Chronic treatment with tacrine, galanthamine, donepezil and NXX-066 increased the number of a4B2 nAChRs in the concentration range of 10...
HIV-1 infection in Tanzania with special reference to early diagnosis in children and preparations for vaccine trials
(2000-05-18)
children included in the study was 19.2%.
We compared the performance of several in-house nested PCR systems to that of the Amplicor (Roche) HIV-1 PCR kit in the detection of HIV-1 DNA in Tanzanian blood samples prepared by the ficoll-isopaque (FIP...
Changes in sensory systems during aging : an experimental study in the rat
(1999-11-26)
Aging is associated with sensorimotor disturbances, including increased proprioceptive thresholds. The present study aimed to clarify the occurrence of structural and biochemical alterations in sensory systems of behaviorally ...
Repression of transcription factor NF-[kappa]B by glucocorticoids : a molecular mechanism for their anti-inflammatory and immuno-modulatory effects
(2000-11-21)
It has been known since the late 1940s that glucocorticoids (GCs) possess anti-inflammatory activity. Their various uses in the clinic include treatment of, rheumatoid arthritis, asthma and AIM skin diseases and also as ...
Menopausal hormone therapy and the risk of esophageal and gastric cancer
(2017-05-24)
A protective effect of female sex hormones has been suggested to explain the male predominance in esophageal and gastric adenocarcinoma, but evidence is lacking. We aimed to test whether menopausal hormone therapy (MHT) ...
Mental and physical health among first-generation and second-generation immigrants in Sweden
(2006-09-11)
-generation immigrants and whether having one parent born in Sweden has a protective effect on this risk (study 2). To examine whether the increased risk of being hospitalized for alcohol and drug abuse among certain immigrant groups is present among second...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...
Clinical studies of glucose variability and hypoglycemia in adult patients with type 1 diabetes
(2011-11-02)
Diabetes mellitus type 1 is a condition characterized by elevated blood glucose values due to impaired insulin production. This condition is associated with increased morbidity from micro- and macrovascular complications. ...
Prognostic and predictive factors in Vietnamese breast cancer : a comparison with Swedish patients and effect on survival
(2012-03-07)
cancer patients and to estimate survival. Primary breast cancer tissues were collected randomly for analysis of hormone receptors, HER2 status and cell proliferation. Clinical information, pathology report and treatment protocols were obtained from...
Atrial fibrillation and lifestyle factors with focus on physical activity and alcohol consumption
(2017-02-06)
The overall aim of this thesis was to investigate how modifiable lifestyle factors, with a focus on alcohol consumption and physical activity, influence the risk of atrial fibrillation (AF). The thesis is based on data ...