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Health effects from pesticide use in Costa Rica : an epidemiologic approach
(1997-09-19)
The use of toxic pesticides is increasing in developing countries, often under unsafe conditions. Poisonings are a well-known but underreported public health problem, and studies on long-term effects are sparse. Therefore, ...
Maternal stress and allergic disease in offspring
(2023-01-03)
of maternal perceived stress at 18- and 34-weeks was described and the association between symptoms of allergic disease and maternal perceived stress explored in n=2164 pregnant mothers. Study 2 described the prevalence of infant colic, abdominal pain...
Role of PfATP6 and pfMRP1 in Plasmodium falciparum resistance to antimalarial drugs
(2009-05-11)
Half of the world's population live at risk for malaria and nearly one million people die from the disease every year. The malaria burden is greatest in children and pregnant women in sub-Saharan Africa. As effective ...
A multifactorial approach to targeting signalling pathways in diabetic foot ulcers
(2019-10-18)
Diabetic foot ulcers (DFU) are one of the most debilitating complication of diabetes that adversely impacts the health, economics and quality of life of the afflicted individual. The primary pathogenic factor of DFU is ...
Helicobacter pylori eradication treatment and the risk of gastric and oesophageal cancer
(2018-12-19)
Helicobacter pylori is a strong and well-established risk factor for gastric cancer, but seems to decrease the risk of oesophageal adenocarcinoma. Thus, eradication treatment for Helicobacter pylori may decrease the risk ...
Regulators of glucose and lipid metabolism in skeletal muscle and serum : implications for obesity and type 2 diabetes
(2012-11-01)
Type 2 diabetes mellitus (T2DM) has become a growing worldwide problem of public health importance. Insulin resistance is commonly associated with obesity and a key factor mediating the progression to T2DM. The failure of insulin...
Determination of transcription factor binding specificities
(2015-11-19)
The term "genetic code" refers to the way in which the information encoded in nucleic acids
is converted into the amino-acid sequence of proteins. There is however also a second genetic
code, one that is used by the cells ...
Using enriched quality register data for health care evaluation : examples from rheumatoid arthritis
(2014-09-24)
to register-identified subjects with RA and estimated the annual societal cost in prevalent as well as monthly societal cost in newly diagnosed patients to 2-3 times higher than in the general population (paper II). The randomized Swefot trial compared...
Screening strategies for dysglycaemia in relation to cardiovascular risk
(2019-01-16)
Background: Dysglycaemia, defined as type 2 diabetes (T2DM) or impaired glucose tolerance (IGT), is a major risk factor for cardiovascular disease (CVD). Dysglycaemia and CVD together account for more than half of worldwide mortality. Despite...
Hormonal regulation of HES-1 in breast cancer cells
(2008-05-21)
that exogenous expression of HES-1 causes cell cycle arrest in the G1 phase of the cell cycle. We found the cell cycle factor E2F-1, critical for G1 to S-phase progression, to be regulated by HES-1, via a cis-element in the 5 regulatory region of the E2F-1 gene...