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Health care in transition : threat or opportunity? Psychosocial work quality and health for staff and organization
(1997-09-23)
Impact of the psychosocial work environment on the health and well-being of health care personnel should be studied with a global view, including individual and organizational resources to cope with work conditions. Work ...
The potential of ambulance records for a road traffic safety agenda in low-income cities : studies from Karachi, Pakistan
(2005-08-30)
-95) and in 2003-2004 (reference period 2003). Common to all studies is the use of Edhi Ambulance Service (EAS) logbooks. In study 1, the epidemiology of childhood RTIs was analysed. Study 2 assessed the magnitude of RTIs for all age groups. EAS logbook data were...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...
In vivo functions of mammalian glutaredoxin 2
(2008-08-29)
isoforms: (1) mitochondrial Grx2a corresponds to human Grx2a, (2) Grx2c is a cytosolic protein homologous to human Grx2c but derived from different transcript variants and (3) Grx2d, an enzymatically inactive protein that lacks structurally important amino...
Rare complications in cancer surgery
(2023-04-28)
Background: Curative cancer surgery aims to reduce mortality and morbidity related symptoms caused by the cancer. The surgery is often done at a time when the patient is presenting lesser or no symptoms and at a time when ...
Studies on anti-inflammatory and vasoactive effects of mPGES-1 inhibition
(2022-12-13)
Inflammation is the basis for various serious illnesses such as rheumatic diseases, cardiovascular diseases, and cancer. Prostaglandin E2 (PGE2) is a pro-inflammatory lipid mediator produced by cyclooxygenases (COX1/2) and the microsomal...
Regulation of B cell responses to modified self
(2013-10-25)
autoreactive B cells in a model where syngeneic apoptotic cells were injected repeatedly to break tolerance to self and induce an autoantibody response. We show that NKT cells make up an important CD1d-dependent check-point for autoreactive B cells prior...
Virulence in Plasmodium falciparum malaria : mechanisms of PfEMP1-mediated rosetting
(2013-11-07)
obstruction is associated with virulence of the parasite. Rosetting, the adhesion of a parasitized red cell (pRBC) to two or more non-parasitized RBC is central in the adhesion phenomena. The adhesin Plasmodium falciparum Erythrocyte Membrane Protein-1 (PfEMP1...
Mechanisms of malignant and non-malignant angiogenesis using zebrafish models
(2010-10-01)
-induced lymphatic perfusion might facilitate tumor cell spread from the blood stream into the lymphatic system. In paper III, we take advantage of the transparent nature of zebrafish embryos and availability of the transgenic strain fli1:EGFP to develop a zebrafish...
Screening strategies for dysglycaemia in relation to cardiovascular risk
(2019-01-16)
. 1) Compare the prognostic value of fasting plasma glucose (FPG), 2h postload glucose (2hPG) and HbA1c in patients with coronary artery disease (CAD) (Study I). 2) Study the prevalence of dysglycaemia in people treated for hypertension and...