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CYP2C19 and CYP2C9 geno- and phenotypes in healthy Swedish and Korean subjects
(2010-12-23)
Cytochrome P450s (CYPs) are responsible for approximately 75% of the phase I-dependent drug metabolism. Several important polymorphisms in these enzymes are known to affect the individual drug response. CYP2C19 and CYP2C9 ...
Different aspects of breast reconstruction : contralateral prophylactic mastectomy, postmastectomy radiotherapy, complications after biomaterials injection
(2012-09-27)
of patients with a personal and family history of breast cancer undergoing contralateral prophylactic mastectomy (CPM) during 1998-2008 (n=91). The findings indicated that CPM was a complex procedure, where the majority of patients (82%) received concurrent...
Clinical and pathophysiological aspects of intrahepatic cholestasis of pregnancy
(2012-11-20)
Objective: The pathogenesis of intrahepatic cholestasis of pregnancy (ICP) involves impaired bile acid and estrogen/progesterone metabolism and excretion based on genetic and environmental factors. In this thesis we evaluated ...
Development and application of an LC-MS method for the alcohol biomarker phosphatidylethanol (PEth) in blood
(2011-11-29)
/N ≥ 3) and limit of quantification (S/N ≥ 10) were ≤ 0.02 and ≤ 0.1 μmol/L, respectively. The calibration curve was linear in the concentration range 0.2-20 μmol/L and the intra-assay CV % for total PEth was ≤ 8.6 % and the inter-assay CV was < 11...
Transurethral resection of the prostate : how to reduce morbidity
(2011-09-30)
of TURP still makes it one of the most common surgical operations worldwide and approximately 6,000 such operations are performed every year in Sweden. However, this surgical technique is not without problems with per- and postoperative bleeding events...
Visually induced ocular torsion
(2011-05-20)
There has been some controversy whether ocular torsion (eye rotation around the line of sight) is induced in response to a tilted visual scene. The aim of this thesis was to investigate if ocular torsion can be induced by ...
Importance of pharmacogenetic and environmental factors for variation in caffeine disposition : with special emphasis on CYP1A2, CYP2A6, NAT2 and XO
(2012-03-12)
). Phenotyping of CYP1A2, CYP2A6, NAT2 and XO was performed using caffeine as a probe drug and measuring concentration of parent compound and its metabolites in plasma or urine samples. CYP1A2 activity was estimated by 17X/137X plasma ratio, and CYP2A6, NAT2...
Analysis of stroma-derived factors with potential prognostic and therapeutic significance in prostate cancer
(2010-09-10)
Prostate cancer is the most common malignancy in Sweden with about 9000 new cases diagnosed every year. New markers are needed to improve diagnostic accuracy. The most commonly used tissue-biomarkers are basal cell markers ...
Pharmacokinetic and pharmacodynamic aspects on opioid administration, morphine and ketobemidone, in the pediatric population
(2012-10-23)
Opioids are the mainstay of the treatment of severe nociceptive pain in both children and adults. The studies in this thesis have focused on different aspects of opioid treatment in the pediatric population with special ...
Pharmacogenetic aspects of HIV/AIDS, tuberculosis and malaria : emphasis on Ugandan population
(2011-10-20)
for the effect of sex and different single nucleotide polymorphisms (SNPs) in ABCB1, CYP2B6 and CYP3A5 genes on single dose pharmacokinetics of efavirenz (n=30) and quinine (n=20). Patients were examined for effects of rifampicin and CYP2B6 (*6 &*11), CYP3A5 (*3...