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Mitochondrial function adaptations to changed metabolic conditions
(2010-09-09)
during normoxia increased its mitochondrial population (+20.8%, P<0.05) and there was a trend towards increased respiratory capacity (+31.2%, P<0.08), while adaptations were absent in the hypoxically trained leg. Altitude training might thus...
Immunological studies on anca-associated vasculitis with special reference to T cell activation
(2009-10-16)
This thesis focuses on the role of T cells in ANCA-associated vasculitis. We initially investigated activation markers on T cells in patients with Wegener's granulomatosis (WG), microscopic polyangiitis (MPA) and renal ...
Studies on cysteinyl leukotriene receptor 1 and 15-lipoxygenase-1 in lymphomas
(2008-08-22)
Classical Hodgkin lymphoma (cHL) is a malignant disorder with striking
inflammatory features. Since cysteinyl leukotrienes (cysLTs) are potent
inflammatory mediators it was of interest to study their potential role
in ...
Issues of validity in longitudinal studies of youth tobacco use
(2009-04-03)
In the Stockholm region, a prospective longitudinal study: BROMS Cohort Study (Children s Smoking and Environment in the Stockholm County) was conducted between 1997 and 2005, with the primary aim to investigate determinants ...
Epidemiological and recovery facilitating studies of an urban population of stroke patients in Iran
(2010-05-28)
Introduction: Approximately 15 million people have a stroke annually in the world, of whom one third will die within one year and one third will suffer permanent disability. Over 85% of these deaths happen in people living ...
Endogenous and exogenous glucocorticoid effects in a model of allergic airway inflammation.
(2008-08-15)
Allergic asthma and rhinitis are inflammatory diseases of the airways. Allergic asthma is characterized by eosinophilic inflammation, reversible bronchoconstriction and airway hyperresponsiveness, whereas patients with ...
Brain volume reduction over four decades in multiple sclerosis
(2010-05-07)
Introduction: Multiple sclerosis (MS) is a common neurological disease causing intermittent or cumulative disability, predominantly among women of child-bearing age. MS is a chronic inflammatory disease of the central ...
Recessive parkinsonism, mitochondria and translational regulation
(2008-09-05)
Three genes are known to cause recessive forms of Parkinson disease (PD) in humans: parkin, PINK1 and DJ-1. Of these, the rarest is DJ-1; less than fifty known cases worldwide are due to mutations in DJ-1. Though rare, ...
Bilateral prophylactic mastectomy and immediate breast reconstruction with implants
(2009-11-20)
Bilateral prophylactic mastectomy (BPM) followed by immediate breast reconstruction (IBR) has been more frequently performed over the last 10 years to prevent breast cancer in high-risk women. Since this procedure is ...
Hypoxia in arterial and venous specification during vascular development
(2009-08-14)
A developing embryo needs a constant supply of oxygen and nutrients in order to survive and grow into a functioning organism. During the earliest embryonic stages passive diffusion is enough to sustain the embryo. At later ...