Karolinska Institutet Open Archive
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Using the force : targeting p60AmotL2-mediated invasion in cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2024-03-28)Mechanotransduction is the process by which cells convert mechanical forces into biochemical signals—and vice versa—thanks to a coordinated cascade of effects regulated by mechanomodulatory and cytoskeletal complexes. ... -
Improvement of microbiological diagnostics in sepsis
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2024-03-27)Sepsis, a life-threatening condition characterized by a dysregulated host response to infection, poses significant diagnostic and therapeutic challenges, contributing to high morbidity and mortality rates worldwide. The ... -
NK cells in renal cell carcinoma : toward biomarker discovery and improved immunotherapeutic strategies
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2024-03-27)Renal cell carcinoma (RCC) represents a significant clinical challenge due to its resistance to conventional therapies and its complex tumor microenvironment (TME). RCC's immunogenic nature, characterized by the infiltration ... -
Heart failure with preserved and reduced ejection fraction : comorbidities, therapies and cause-specific outcomes
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-03-27)Background: Heart failure (HF) is associated with worse prognosis and poor quality of life, and its rising global prevalence puts a growing strain on healthcare systems. While most previous studies have focused on ... -
Pharmacovigilance of mass drug administration as preventive chemotherapy to control and eliminate lymphatic filariasis in Tanzania
(Inst för global folkhälsa / Dept of Global Public Health, 2024-03-27)Mass drug administration (MDA) campaigns are usually conducted on an annual basis by many countries globally where neglected tropical diseases (NTDs), including lymphatic filariasis (LF), are endemic. Such campaigns are ...