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Aspects of the etiology and survival of lower gastrointestinal cancers
(2010-02-26)
fissure, fistula, and perianal abscess), and 79,808 patients were hospitalized with hemorrhoids. Patients with inflammatory anal lesions had a 3-fold increased risk of anal cancer that persisted over time. There was no persistent risk elevation in patients...
Genome-wide study of HDACs and transcription in Schizosaccharomyces pombe
(2010-05-27)
at silent regions and in repression and activation of gene expression. We proposed that independent of gene length, a typical fission yeast gene shows a 5 to 3 polarity, i.e., the histone acetylation levels peak near the ATG and gradually decrease...
Sox proteins and neurogenesis
(2010-04-02)
the role of Sox21 in regulating neurogenesis. We show that Sox21 promotes neurogenesis, opposite to the activity of the SoxB1 factors (Sox1-3) that has been shown to repress neurogenesis. Sox21 and Sox1-3 bind a similar set of target genes and the effect...
Management of dental clinics by the use of informatics
(2009-04-24)
The main objective with this project has been to develop a tool for close to-the-clinic healthcare management, based upon ways of measuring which are interpretable both by professionals as well as by patients. This would ...
Studies on hereditary spastic paraplegia proteins
(2010-05-14)
different HSP proteins: atlastin-1, a member of the dynamin superfamily of large GTPases through sequence similarity, and maspardin Mast syndrome, spastic paraplegia, autosomal recessive with dementia. Mutations in the atlastin-1 gene, SPG3A, are the second...
Immunological studies on anca-associated vasculitis with special reference to T cell activation
(2009-10-16)
This thesis focuses on the role of T cells in ANCA-associated vasculitis. We initially investigated activation markers on T cells in patients with Wegener's granulomatosis (WG), microscopic polyangiitis (MPA) and renal ...
Characterization of dopamine D1 receptor agonists in vivo : implications for the treatment of schizophrenia and Parkinson's disease
(2008-05-14)
Dopamine is fundamental in human behavior for movement, cognition and
reward. A dysfunctional dopamine system is implicated in several
neurological and psychiatric disorders such as Parkinson s disease and
schizophrenia. ...
Disaster and recovery
(2010-08-19)
Background: Most people who survive a disaster respond with psychological reactions, but only a minority suffer from lasting psychological problems. Despite evidence of the significance of specific exposures for impaired ...
Genetic and functional analyses of diabetic nephropathy with focus on chromosome 3q
(2010-05-14)
were ex-amined with kidney tissues of db/db mice. The ADIPOQ gene is located in chromosome 3q27.3. A promoter single nucleotide polymorphism (SNP) rs266729 in the gene was found to be associated with DN in female T1D patients. This polymorphism altered...
Morphology and biochemistry of the tympanic membrane in relation to retraction pathology
(2010-03-10)
Otitis media is very common during childhood and may predispose for tympanic membrane (TM) pathology later in life. Therefore, it is important to investigate the possible changes in TMs subjected to otitis media.
There ...