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Aprotinin for reduction of bleeding and transfusions in patients on clopidogrel undergoing urgent coronary surgery
(2009-05-08)
percentile) adenosinediphosphate mediated platelet aggregation before and after aprotinin, was 84% (76/91) and 94% (86/97, p<0.01). Clopidogrel non-responders with >90% aggregation (n=4) had a median aggregation of 94.5% (91.5/97.5) versus 82% (73/87, p<0...
Ligand binding and mechanism of microsomal glutathione transferase 1
(2009-01-09)
spectrometry, binding of three GSH molecules was observed within the trimer while the monomer did not bind GSH, in agreement to the proposed binding sites at subunit interfaces (Holm, et al., (2006). J. Mol. Biol. 360(5): 934-945). The binding of GSH could...
Aciclovir-induced neuropsychiatric symptoms : a clinical pharmacology study
(2010-08-13)
Aciclovir (ACV) and its prodrug valacyclovir (VACV) are used to treat infections caused by herpes simplex virus (HSV) and varicella zoster virus (VZV), and as prophylaxis against cytomegalovirus (CMV) infections in ...
The role of CYP3A4/5 in alprazolam metabolism
(2010-05-14)
Cytochrome P450 3A (CYP3A) enzyme family is involved in the metabolism of about 50 % of all drugs in clinical use. Among CYP3A, CYP3A4 and CYP3A5 are the major enzymes in adults; however CYP3A5 is polymorphic and primarily expressed in black...
Evaluation of strategies to predict and improve early graft survival in clinical islet transplantation
(2010-05-21)
Transplantation of the islets of Langerhans as a treatment for type 1
diabetes (T1DM) is a procedure still under development. For the last
decade it has been possible to obtain insulin independence by repeated
infusions ...
Studies on cysteinyl leukotriene receptor 1 and 15-lipoxygenase-1 in lymphomas
(2008-08-22)
Classical Hodgkin lymphoma (cHL) is a malignant disorder with striking
inflammatory features. Since cysteinyl leukotrienes (cysLTs) are potent
inflammatory mediators it was of interest to study their potential role
in ...
Manipulating neural stem cells
(2010-03-17)
one factor, Oct4. In manuscript IV Oct4 expression is chemically induced. Endogenous expression of the pluripotency factors Nanog and Rex1 were measured to investigate whether Oct4-inducing conditions could lead to a reprogrammed state....
You are how you eat : decelerated eating may protect from obesity and eating disorders
(2009-05-14)
On a new framework for anorexia nervosa, learning to eat is central intervention; as patients regain a normal pattern of eating their problems dissolve. Mandometer®, a development of previous methods, allows simultaneous ...
A longitudinal study of dentofacial morphology in young children treated for the obstructive sleep apnoea syndrome
(2008-09-19)
The most common cause of OSAS in children is enlarged tonsils and/or adenoids. Consequently, the treatment for OSAS in children with enlarged tonsils and/or adenoids is adeno-/tonsillectomy. The prevalence of OSAS in ...
Evaluations of measurement techniques in functional dyspepsia : electrogastrography, satiety drinking test and 14C-urea breath test
(2010-08-20)
The overall aim of this thesis was to evaluate the clinical usefulness of certain measurement techniques that may be helpful in the understanding of functional dyspepsia (FD). Electrogastrography (EGG) parameters were ...